1. How will the RB depth chart stack up? After Frank Gore carried the ball 282 times in the regular season last year -- or 29.9 percent of the 49ers' plays -- the team strengthened the depth chart by signing veteran Brandon Jacobs and drafting Oregon's LaMichael James in the second round. Gore is still the go-to guy, but after six years as the team's feature back, it's time to consider lightening his load. Kendall Hunter remains the de facto No. 2 after an impressive rookie season in which he ran for 473 yards on 112 carries, but he'll be in direct competition for carries with James, who left Oregon after three seasons as the NCAA's active rushing leader (5,082 yards). If Jacobs makes the team, it'll likely be because he proved he can still be effective in short-yardage situations -- a role that used to belong to Anthony Dixon, who saw his carries drop from 70 in his rookie year to just 29 last season.
2. Which Randy Moss is the team getting? Throughout the offseason, 49ers players and coaches were united in evaluating Moss as an ideal teammate. It's quite the contradiction from the guy former Vikings coach Brad Childress described as someone who figuratively “walked in the [Vikings'] locker room and vomited on it.” For Moss, remaining in the good graces of his teammates is a good first step, but ultimately his value will be determined by his play. So far, so good. There wasn't a moment during offseason workouts where Moss didn't look like the team's best receiver.
3. Can a relative unknown make the roster? The knee-jerk answer to this question is a resounding “No.” Depth is not an issue on this team, so it'll be difficult for an undrafted rookie or a lesser-tier free agent to stick on the team's 53-man roster. If they do, it'll likely be because they show versatility on special teams.
4. Will the draft picks carve out roles? A.J. Jenkins has a chance to be secondary kickoff return option next to Ted Ginn Jr., but his role in the passing game will likely progress slowly. With Michael Crabtree, Mario Manningham and Moss on the roster, the team can take its time developing the first-round pick. Like Jenkins, LaMichael James could see time backing up Ginn in the return game, but the team will also find ways to get him the ball on offense. Fourth-round pick Joe Looney has not fully recovered from a foot injury he suffered at the Senior Bowl in January and will begin the season on the non-football injury list, the team announced Monday. Darius Fleming was placed on the Physically Unable to Perform list Monday and will miss the season due to a torn ACL he suffered during the first day of rookie minicamp in May. DB Trenton Robinson, OL Jason Slowey and DE/OLB Cam Johnson all face stiff competition just to make the team.
5. Is Alex Boone the starter at RG? A converted OT, Alex Boone was tabbed by coach Jim Harbaugh as first in line to win the RG job vacated by Adam Snyder's departure to Arizona. Harbaugh said he was pleased with Boone's progress during offseason workouts but acknowledged that evaluating players on the OL without pads is just about impossible. Daniel Kilgore and Mike Person should also compete for the job.
Follow 49ers reporter Kyle Bonagura on Twitter: @KyleBonagura and @CBSSportsNFLSF.