| Draft History | |||||||
| Year | Round | Pick | Overall Pick | Team | Name | Position | College |
| 2008 | 2 | 1 | 32 | Dolphins | *Phillip Merling | DE | Clemson |
| 1989 | 5 | 1 | 113 | Cowboys | Keith Jennings | TE | Clemson |
| 1979 | 10 | 1 | 249 | 49ers | Dwight Clark | WR | Clemson |
| 1974 | 6 | 1 | 131 | Chiefs | Jim Washington | RB | Clemson |
| 2007 | 5 | 2 | 139 | Rams | Dustin Fry | C | Clemson |
| 1985 | 3 | 2 | 58 | Giants | Tyrone Davis | DB | Clemson |
| 1982 | 9 | 2 | 225 | Colts | Tony Berryhill | C | Clemson |
| 1981 | 6 | 2 | 140 | Seahawks | Steve Durham | DE | Clemson |
| 1979 | 11 | 2 | 277 | Chiefs | Stan Rome | WR | Clemson |
| 2010 | 5 | 3 | 134 | Eagles | Ricky Sapp | OLB | Clemson |
| 2009 | 4 | 3 | 103 | Rams | Darell Scott | DT | Clemson |
| 1991 | 4 | 3 | 86 | Cardinals | Dexter Davis | DB | Clemson |
| 1987 | 2 | 3 | 31 | Falcons | Kenny Flowers | RB | Clemson |
| 1984 | 6 | 3 | 143 | Giants | Jim Scott | DE | Clemson |
| 1983 | 11 | 3 | 282 | Rams | Danny Triplett | LB | Clemson |
| 2008 | 6 | 4 | 170 | Chiefs | Barry Richardson | OT | Clemson |
| 2007 | 1 | 4 | 4 | Bucs | Gaines Adams | DE | Clemson |
| 2005 | 5 | 4 | 140 | Bears | Airese Currie | WR | Clemson |
| 1985 | 5 | 4 | 116 | Cardinals | K.D. Dunn | TE | Clemson |
| 1971 | 2 | 4 | 30 | Lions | Dave Thompson | C | Clemson |
| 1992 | 5 | 5 | 117 | Chargers | Curtis Whitley | C | Clemson |
| 1979 | 1 | 5 | 5 | Bills | Jerry Butler | WR | Clemson |
| 1999 | 5 | 6 | 139 | Chargers | Adrian Dingle | DE | Clemson |
| 1998 | 5 | 6 | 129 | Rams | Raymond Priester | RB | Clemson |
| 1998 | 6 | 6 | 159 | Rams | Glenn Rountree | G | Clemson |
| 1996 | 5 | 6 | 138 | Redskins | Leomont Evans | DB | Clemson |
| 1991 | 5 | 6 | 117 | Cardinals | Vance Hammond | DT | Clemson |
| 1989 | 10 | 6 | 257 | Buccaneers | Ty Granger | OT | Clemson |
| 1982 | 1 | 6 | 6 | Seahawks | Jeff Bryant | DE | Clemson |
| 1973 | 11 | 6 | 266 | Bears | Ed Siegler | K | Clemson |
| 1969 | 14 | 6 | 344 | Patriots | John Cagle | LB | Clemson |
| 1993 | 4 | 7 | 91 | Buccaneers | Rudy Harris | RB | Clemson |
| 1984 | 3 | 7 | 63 | Falcons | Rod McSwain | DB | Clemson |
| 1995 | 6 | 8 | 179 | Buccaneers | Wardell Rouse | LB | Clemson |
| 1985 | 10 | 8 | 260 | Buccaneers | Donald Igwebuike | K | Clemson |
| 1979 | 3 | 8 | 64 | Cardinals | Joe Bostic | OT | Clemson |
| 1972 | 14 | 8 | 346 | Packers | Larry Hefner | LB | Clemson |
| 1968 | 3 | 8 | 64 | Browns | Harry Olszewski | OG | Clemson |
| 2010 | 1 | 9 | 9 | Bills | C.J. Spiller | RB | Clemson |
| 2004 | 3 | 9 | 72 | Packers | Donnell Washington | DT | Clemson |
| 1994 | 7 | 9 | 203 | Browns | Andre Hewitt | OT | Clemson |
| 1983 | 8 | 9 | 205 | Giants | Andy Headen | LB | Clemson |
| 1972 | 9 | 9 | 217 | Steelers | Don Kelley | DB | Clemson |
| 1970 | 14 | 9 | 347 | 49ers | Jack King | G | Clemson |
| 2010 | 4 | 10 | 108 | Raiders | Jacoby Ford | WR | Clemson |
| 1998 | 4 | 10 | 102 | Dolphins | Lorenzo Bromell | DT | Clemson |
| 1997 | 2 | 10 | 40 | Rams | Dexter McCleon | DB | Clemson |
| 1992 | 2 | 10 | 38 | Steelers | Levon Kirkland | LB | Clemson |
| 1987 | 2 | 10 | 38 | Steelers | Delton Hall | DB | Clemson |
| 1983 | 1 | 10 | 10 | Giants | Terry Kinard | DB | Clemson |
| 1983 | 3 | 10 | 66 | Saints | Cliff Astin | RB | Clemson |
| 1979 | 4 | 10 | 92 | Lions | Jonathan Brooks | LB | Clemson |
| 1989 | 1 | 11 | 11 | Bears | Donnell Woolford | DB | Clemson |
| 1983 | 11 | 11 | 290 | Seahawks | Bob Mayberry | G | Clemson |
| 1983 | 12 | 11 | 318 | Giants | Frank Magwood | WR | Clemson |
| 1972 | 3 | 11 | 63 | Steelers | John McMakin | TE | Clemson |
| 1968 | 9 | 11 | 230 | Redskins | Frank Liberatore | DB | Clemson |
| 1990 | 10 | 12 | 260 | Saints | Gary Cooper | WR | Clemson |
| 1985 | 6 | 12 | 152 | Falcons | Reggie Pleasant | DB | Clemson |
| 1984 | 12 | 12 | 320 | Dolphins | William Devane | DT | Clemson |
| 1981 | 7 | 12 | 178 | Colts | Obed Ariri | K | Clemson |
| 1976 | 11 | 12 | 303 | Giants | Craig Brantley | WR | Clemson |
| 1992 | 5 | 13 | 125 | Vikings | Ed McDaniel | LB | Clemson |
| 1989 | 4 | 13 | 97 | Broncos | Richad McCullough | DE | Clemson |
| 2004 | 3 | 14 | 77 | 49ers | Derrick Hamilton | WR | Clemson |
| 1999 | 2 | 14 | 45 | Browns | Rahim Abdullah | LB | Clemson |
| 1991 | 2 | 14 | 41 | Patriots | Jerome Henderson | DB | Clemson |
| 1970 | 3 | 14 | 66 | Cowboys | Charlie Waters | DB | Clemson |
| 2006 | 1 | 15 | 15 | Rams | Tye Hill | CB | Clemson |
| 2001 | 1 | 15 | 15 | Redskins | Rod Gardner | WR | Clemson |
| 1998 | 1 | 15 | 15 | Seahawks | Anthony Simmons | LB | Clemson |
| 1993 | 1 | 15 | 15 | Packers | Wayne Simmons | LB | Clemson |
| 1984 | 11 | 15 | 295 | Vikings | Edgar Pickett | LB | Clemson |
| 1993 | 3 | 16 | 72 | Raiders | James Trapp | DB | Clemson |
| 1992 | 1 | 16 | 16 | Raiders | Chester McGlockton | DT | Clemson |
| 1968 | 4 | 16 | 99 | Bears | Wayne Mass | OT | Clemson |
| 2006 | 3 | 17 | 81 | Chargers | Charlie Whitehurst | QB | Clemson |
| 2003 | 4 | 17 | 114 | Broncos | Nicholas Eason | DT | Clemson |
| 1988 | 12 | 17 | 322 | Steelers | James Earle | LB | Clemson |
| 1984 | 8 | 17 | 213 | Cardinals | Bob Paulling | K | Clemson |
| 1983 | 4 | 17 | 101 | Patriots | Johnny Rembert | LB | Clemson |
| 1982 | 5 | 17 | 128 | Buccaneers | Jeff David | LB | Clemson |
| 1978 | 5 | 17 | 127 | 49ers | Archie Reese | DT | Clemson |
| 1976 | 10 | 17 | 282 | Dolphins | Don Testerman | RB | Clemson |
| 1984 | 12 | 18 | 326 | Broncos | Murray Jarman | WR | Clemson |
| 1987 | 4 | 19 | 103 | Bengals | Jim Riggs | TE | Clemson |
| 1983 | 11 | 19 | 298 | Vikings | Brian Butcher | G | Clemson |
| 1982 | 1 | 19 | 19 | Bills | Perry Tuttle | WR | Clemson |
| 1980 | 12 | 19 | 324 | Colts | Marvin Sims | RB | Clemson |
| 1978 | 8 | 19 | 213 | Jets | Roy Eppes | DB | Clemson |
| 1969 | 8 | 19 | 201 | Cardinals | Wayne Mulligan | C | Clemson |
| 1967 | 14 | 19 | 360 | Browns | Floyd Rogers | OT | Clemson |
| 1996 | 2 | 20 | 50 | Chargers | Patrick Sapp | LB | Clemson |
| 1989 | 10 | 20 | 271 | Oilers | Tracy Johnson | RB | Clemson |
| 1980 | 1 | 20 | 20 | 49ers | Jim Stuckey | DT | Clemson |
| 1998 | 7 | 21 | 210 | Dolphins | Jim Bundren | G | Clemson |
| 1994 | 2 | 21 | 50 | Steelers | Brentson Buckner | DE | Clemson |
| 1991 | 10 | 21 | 271 | Eagles | Eric Harmon | G | Clemson |
| 1990 | 9 | 21 | 241 | Vikings | Terry Allen | RB | Clemson |
| 1985 | 3 | 21 | 77 | Rams | Dale Hatcher | P | Clemson |
| 1982 | 7 | 21 | 188 | Chargers | Hollis Hall | DB | Clemson |
| 1982 | 12 | 21 | 327 | Broncos | Brian Clark | G | Clemson |
| 1976 | 15 | 21 | 424 | Colts | Gary Alexander | OT | Clemson |
| 2009 | 6 | 22 | 195 | Browns | James Davis | RB | Clemson |
| 2007 | 5 | 22 | 159 | Eagles | *C.J. Gaddis | FS | Clemson |
| 1993 | 4 | 22 | 106 | Vikings | Ashley Sheppard | LB | Clemson |
| 1985 | 1 | 22 | 22 | Bears | William Perry | DT | Clemson |
| 1991 | 3 | 23 | 78 | Bears | Chris Gardocki | P | Clemson |
| 1991 | 11 | 23 | 301 | Bears | Stacy Long | G | Clemson |
| 1988 | 2 | 23 | 50 | Browns | Michael Dean Perry | DT | Clemson |
| 1983 | 5 | 23 | 135 | Cowboys | Chuck McSwain | RB | Clemson |
| 1979 | 1 | 23 | 23 | Chiefs | Steve Fuller | QB | Clemson |
| 1970 | 11 | 23 | 283 | Cowboys | Ivan Southerland | OT | Clemson |
| 1968 | 5 | 23 | 134 | Browns | Jackie Jackson | RB | Clemson |
| 1993 | 6 | 24 | 164 | Dolphins | Robert O'Neal | DB | Clemson |
| 1991 | 2 | 24 | 51 | Seahawks | Doug Thomas | WR | Clemson |
| 1980 | 7 | 24 | 189 | Cowboys | Lester Brown | RB | Clemson |
| 2007 | 7 | 25 | 235 | Jets | Chansi Stuckey | WR | Clemson |
| 2005 | 2 | 25 | 57 | Jets | Justin Miller* | CB | Clemson |
| 1999 | 1 | 25 | 25 | Packers | Antwan Edwards | DB | Clemson |
| 1999 | 7 | 25 | 231 | Giants | O.J. Childress | LB | Clemson |
| 1987 | 1 | 25 | 25 | 49ers | Terrence Flagler | RB | Clemson |
| 1973 | 6 | 25 | 155 | Jets | Rick Harrell | C | Clemson |
| 1991 | 2 | 26 | 53 | 49ers | John Johnson | LB | Clemson |
| 1990 | 10 | 26 | 274 | Giants | Otis Moore | DT | Clemson |
| 1988 | 3 | 26 | 81 | Saints | Tony Stephens | DT | Clemson |
| 1983 | 7 | 26 | 194 | Raiders | Jeff McCall | RB | Clemson |
| 1978 | 11 | 27 | 305 | Broncos | Lacy Brumley | OT | Clemson |
| 1997 | 1 | 28 | 28 | Broncos | Trevor Pryce | DE | Clemson |
| 1976 | 1 | 28 | 28 | Steelers | Bennie Cummingham | TE | Clemson |
| 2009 | 5 | 29 | 165 | Dolphins | Chris Clemons | FS | Clemson |
| 2009 | 5 | 30 | 166 | Cowboys | Mike Hamlin | FS | Clemson |
| 2003 | 4 | 31 | 128 | Broncos | Bryant McNeal | DE | Clemson |
| 1996 | 2 | 31 | 61 | Eagles | Brian Dawkins | DB | Clemson |
| 2001 | 7 | 32 | 232 | Titans | Keith Adams | LB | Clemson |
| 2010 | 5 | 33 | 164 | Steelers | Crezdon Butler | CB | Clemson |
| 2010 | 7 | 33 | 240 | Colts | Kavell Conner | OLB | Clemson |
| 2007 | 3 | 33 | 96 | Chargers | Anthony Waters | ILB | Clemson |
| 2006 | 7 | 33 | 241 | Bucs | Charles Bennett | DE | Clemson |
| 2005 | 3 | 35 | 98 | Seahawks | Leroy Hill | ILB | Clemson |
| 1999 | 5 | 36 | 169 | Vikings | Chris Jones | LB | Clemson |
| 1999 | 7 | 43 | 249 | Bengals | Donald Broomfield | DE | Clemson |
| 2001 | 7 | 44 | 244 | Chargers | Robert Carswell | DB | Clemson |
