| Draft History | |||||||
| Year | Round | Pick | Overall Pick | Team | Name | Position | College |
| 2010 | 1 | 20 | 20 | Texans | Kareem Jackson | CB | Alabama |
| 2009 | 3 | 13 | 77 | Texans | Antoine Caldwell | OG | Alabama |
| 2006 | 2 | 1 | 33 | Texans | DeMeco Ryans | OLB | Alabama |
| 2010 | 3 | 17 | 81 | Texans | Earl Mitchell | DT | Arizona |
| 2009 | 7 | 14 | 223 | Texans | Troy Nolan | FS | Arizona State |
| 2005 | 5 | 15 | 151 | Texans | Drew Hodgdon | C | Arizona State |
| 2010 | 2 | 26 | 58 | Texans | Ben Tate | RB | Auburn |
| 2009 | 2 | 14 | 46 | Texans | Connor Barwin | DE | Cincinnati |
| 2003 | 3 | 3 | 67 | Texans | Antwan Peek | OLB | Cincinnati |
| 2010 | 6 | 18 | 187 | Texans | Shelley Smith | OG | Colorado State |
| 2006 | 7 | 43 | 251 | Texans | David Anderson | WR | Colorado State |
| 2008 | 3 | 16 | 79 | Texans | Antwaun Molden | CB | Eastern Kentucky |
| 2002 | 2 | 1 | 33 | Texans | Jabar Gaffney | WR | Florida |
| 2005 | 1 | 16 | 16 | Texans | Travis Johnson | DT | Florida State |
| 2002 | 1 | 1 | 1 | Texans | David Carr | QB | Fresno State |
| 2005 | 7 | 13 | 227 | Texans | Kenneth Pettway | OLB | Grambling State |
| 2005 | 4 | 13 | 114 | Texans | Jerome Mathis | WR | Hampton |
| 2007 | 7 | 8 | 218 | Texans | Zach Diles | ILB | Kansas State |
| 2002 | 6 | 1 | 173 | Texans | Demarcus Faggins | DB | Kansas State |
| 2007 | 3 | 9 | 73 | Texans | Jacoby Jones | WR | Lane (TN) |
| 2005 | 6 | 14 | 188 | Texans | C.C. Brown | SS | Louisiana-Lafayette |
| 2007 | 1 | 10 | 10 | Texans | Amobi Okoye | DT | Louisville |
| 2003 | 3 | 24 | 88 | Texans | Dave Ragone | QB | Louisville |
| 2003 | 7 | 3 | 217 | Texans | Curry Burns | SS | Louisville |
| 2010 | 6 | 28 | 197 | Texans | Trindon Holliday | WR | LSU |
| 2003 | 4 | 4 | 101 | Texans | Domanick Davis | RB | LSU |
| 2002 | 6 | 18 | 190 | Texans | Howard Green | DT | LSU |
| 2002 | 3 | 18 | 83 | Texans | Charles Hill | DT | Maryland |
| 2006 | 3 | 2 | 66 | Texans | Eric Winston | OT | Miami |
| 2003 | 1 | 3 | 3 | Texans | Andre Johnson | WR | Miami |
| 2010 | 4 | 4 | 102 | Texans | Darryl Sharpton | ILB | Miami (Fla.) |
| 2003 | 2 | 9 | 41 | Texans | Ben Joppru | TE | Michigan |
| 2003 | 6 | 19 | 192 | Texans | Drew Henson | QB | Michigan |
| 2008 | 6 | 7 | 173 | Texans | Dominique Barber | FS | Minnesota |
| 2002 | 7 | 18 | 229 | Texans | Greg White | DE | Minnesota |
| 2004 | 6 | 35 | 200 | Texans | Charlie Anderson | DE | Mississippi |
| 2003 | 6 | 41 | 214 | Texans | Keith Wright | DT | Missouri |
| 2004 | 6 | 10 | 175 | Texans | Jammal Lord | SS | Nebraska |
| 2009 | 4 | 12 | 112 | Texans | Glover Quin | CB | New Mexico |
| 2002 | 5 | 1 | 136 | Texans | Jarrod Baxter | RB | New Mexico |
| 2009 | 4 | 22 | 122 | Texans | Anthony Hill | TE | North Carolina State |
| 2006 | 1 | 1 | 1 | Texans | *Mario Williams | DE | North Carolina State |
| 2003 | 3 | 11 | 75 | Texans | Seth Wand | OT | Northwest Missouri State |
| 2010 | 5 | 13 | 144 | Texans | Sherrick McManis | CB | Northwestern |
| 2004 | 4 | 26 | 122 | Texans | Glenn Earl | SS | Notre Dame |
| 2004 | 6 | 5 | 170 | Texans | Vontez Duff | CB | Notre Dame |
| 2002 | 4 | 1 | 99 | Texans | Jonathan Wells | RB | Ohio State |
| 2005 | 3 | 9 | 73 | Texans | Vernand Morency* | RB | Oklahoma State |
| 2010 | 7 | 20 | 227 | Texans | Dorin Dickerson | TE | Pittsburgh |
| 2006 | 3 | 1 | 65 | Texans | Charles Spencer | OG | Pittsburgh |
| 2002 | 5 | 18 | 153 | Texans | Ramone Walker | DB | Pittsburgh |
| 2009 | 5 | 16 | 152 | Texans | James Casey | TE | Rice |
| 2004 | 7 | 9 | 210 | Texans | Raheem Orr | DE | Rutgers |
| 2002 | 2 | 18 | 50 | Texans | Chester Pitts | G | San Diego State |
| 2007 | 4 | 24 | 123 | Texans | Fred Bennett | CB | South Carolina |
| 2004 | 1 | 10 | 10 | Texans | Dunta Robinson | CB | South Carolina |
| 2009 | 1 | 15 | 15 | Texans | Brian Cushing | ILB | Southern California |
| 2007 | 5 | 7 | 144 | Texans | Brandon Harrison | SS | Stanford |
| 2002 | 3 | 1 | 66 | Texans | Fred Weary | C | Tennessee |
| 2008 | 5 | 18 | 151 | Texans | Frank Okam | DT | Texas |
| 2007 | 6 | 9 | 183 | Texans | Kasey Studdard | OG | Texas |
| 2004 | 7 | 10 | 211 | Texans | Sloan Thomas | WR | Texas |
| 2003 | 7 | 19 | 233 | Texans | Chance Pearce | C | Texas A&M |
| 2004 | 7 | 47 | 248 | Texans | B.J. Symons | QB | Texas Tech |
| 2002 | 7 | 50 | 261 | Texans | Ahmad Miller | DT | UNLV |
| 2009 | 6 | 15 | 188 | Texans | Brice McCain | CB | Utah |
| 2006 | 6 | 1 | 170 | Texans | Wali Lundy | RB | Virginia |
| 2008 | 1 | 26 | 26 | Texans | Duane Brown | OT | Virginia Tech |
| 2008 | 4 | 19 | 118 | Texans | Xavier Adibi | OLB | Virginia Tech |
| 2007 | 5 | 26 | 163 | Texans | Brandon Frye | OT | Virginia Tech |
| 2008 | 7 | 16 | 223 | Texans | Alex Brink | QB | Washington State |
| 2008 | 3 | 26 | 89 | Texans | *Steve Slaton | RB | West Virginia |
| 2004 | 1 | 27 | 27 | Texans | Jason Babin | DE | Western Michigan |
| 2010 | 4 | 20 | 118 | Texans | Garrett Graham | TE | Wisconsin |
| 2006 | 4 | 1 | 98 | Texans | Owen Daniels | TE | Wisconsin |
