He was responsible for 28 touchdowns, which ranked as the third-highest single-season total in school history, and his passing touchdown total ranked fourth on UA's single-season list. He broke Arkansas' single-season record with 498 plays of total offense and his 3,635 yards of total offense ranked as the second-highest single-season total in school history and was the 10th-highest single-season total in SEC history. Wilson's attempt-to-interceptions ratio of 1:73 was the third-highest in SEC history with a minimum of 300 attempts and fourth-highest in conference history with a minimum of 200 attempts. He was a finalist for the Manning Award and the Johnny Unitas Golden Arm Award and a semifinalist for the Davey O'Brien Award. He broke Arkansas' record for consecutive passes without an interception by throwing 184 passes, stretching from the second quarter at Alabama to the second quarter vs. South Carolina, between interceptions. His streak also ranked as the sixth longest in SEC history.
Wilson led the SEC and ranked 16th in the NCAA with his average of 279.8 passing yards per game and led the SEC and ranked 23rd in the NCAA with his average of 279.6 yards of total offense per game. His completions total was the highest in the SEC and ranked 25th in the NCAA, and his 24 touchdown passes ranked second in the conference and 32nd in the nation. Wilson's pass efficiency rating of 148.35 led the SEC and ranked 22nd in the NCAA, and his completion percentage ranked third in the SEC. He ranked third in the SEC and was tied for 13th in the NCAA with his average of 13.13 yards per completion, and his average of 8.31 yards per pass attempt ranked second in the SEC and tied for 18th in the NCAA. He led the SEC and ranked seventh in the NCAA with 94 passes of at least 15 yards and led the SEC and ranked eighth in the country with 33 passes of 25-plus yards. His 61 passes of 15-plus yards in the first half led the conference and ranked fourth in the NCAA, and his 2,179 first-half passing yards led the SEC and was 10th in the nation. He also led the SEC and ranked eighth in the NCAA with 1,261 passing yards in the second quarter. Wilson opened the season with the ninth-highest single-game completion percentage in school history with an 18-of-24 performance for 261 yards and two touchdowns in a 51-7 win vs. Missouri State.
He was 18-of-26 passing for 259 yards and one touchdown through the air and also added 48 rushing yards on five carries in a 52-3 victory vs. New Mexico. Wilson passed for 303 yards and two touchdowns while completing 23-of-36 passes in the 38-28 win vs. Troy. At No. 3 Alabama, he was 22-of-35 passing for 185 yards and two touchdowns. Wilson was named SEC co-Offensive Player of the Week after breaking the Arkansas school record with 510 passing yards while leading the Razorbacks from an 18-point halftime deficit to a 42-38 victory vs. No. 14 Texas A&M inside Cowboys Stadium. He finished the day 30-of-51 passing for 510 yards and three touchdowns, breaking the UA record for pass attempts and producing the fifth 500-yard passing game in SEC history and first since 2001. His passing yards total was the highest in the SEC and the fourth-highest single-game total in the NCAA in 2011. He also broke the Arkansas single-game record with 481 yards of total offense, which was the most in the SEC and 12th-highest single-game total in the NCAA, and with 57 plays of total offense against the Aggies.
Wilson completed a career-high 18 consecutive passes in Arkansas' 38-14 win vs. No. 15 Auburn, which tied for the third-longest overall streak in SEC history and tied for the second-longest single-game streak in conference history. He finished the game against the Tigers 24-of-36 passing for 262 yards and two touchdowns through the air and also added one rushing touchdown. Wilson was 13-of-28 passing for 232 yards and rushed for two touchdowns in the 29-24 win at Ole Miss in which he led the team back from a 17-point deficit. He completed 27-of-43 passes for 316 yards and one touchdown in a 31-28 win at Vanderbilt, leading the Razorbacks back from 14 points down. He was 20-of-37 passing for 299 yards and two touchdowns, including a career-long 68 yarder, in the 44-28 win vs. No. 10 South Carolina.
He completed 16-of-26 passes for 224 yards and three touchdowns in a 49-7 win vs. Tennessee. Wilson was named SEC Offensive Player of the Week for his performance in Arkansas' 44-17 victory vs. Mississippi State in which he broke the school record with 32 completions, bettering the previous record of 31 that had stood since 1971. He finished the game 32-of-43 passing for 365 yards and three touchdowns. At No. 1 LSU, Wilson was 14-of-22 passing for 207 yards and one touchdown. He was named Offensive MVP of the Cotton Bowl after he was 20-of-31 passing for 216 yards and two touchdowns with no interceptions while leading the Razorbacks to a 29-16 win vs. No. 11 Kansas State.
His four touchdowns were the most the Tigers had allowed at home since 2000, and his 332 passing yards were the most given up by an Auburn defense inside Jordan-Hare Stadium since 2001. The next week, he again stepped in for an injured Mallett and was 3-of-5 passing for 71 yards while finishing off a 38-24 win vs. Ole Miss. He was 4-of-5 passing for 36 yards in the Razorbacks' 58-21 victory vs. UTEP. He completed one pass for eight yards in UA's 49-14 win vs. Vanderbilt and opened the season with one completion for six yards in a 44-3 victory vs. Tennessee Tech. He played the final two offensive series but did not attempt a pass in Arkansas' 41-20 win at No. 18 South Carolina.
As a senior, he led Greenwood High School to its third straight state title-second with Wilson starting at quarterback-while passing for 3,939 yards and 42 touchdowns for coach Rick Jones. He was named the MVP of the 5A state championship game. He was also named as one of two quarterbacks on the Associated Press Super Team following his senior season after completing 294 of 473 passes. He also rushed 65 times for 199 yards and four touchdowns. He was recognized with the Landers Award as the state of Arkansas' top player and selected an all-conference and all-state performer. He was a 2007 all-state selection.
As a junior, he completed 294-of-434 passes for 4,222 yards and 50 touchdowns. The No. 9 pro-style quarterback in the nation, as rated by Rivals.com, he was also ranked the No. 5 overall recruit in the state of Arkansas by the same scouting service. He was rated No. 10 overall in the state by the HawgSports.com Natural 21 rankings and No. 6 by Hawgs Illustrated. He was ranked, by Scout.com, as the No. 35 quarterback in the nation and the No. 7 player in Arkansas. He was also recruited by Kansas, Minnesota, Missouri and Nebraska.