His 64.1% career completion rate was just shy of Heisman winner Matt Leinart's USC record of 64.8%. He threw at least 1 TD pass in 42 of his 47 career games, at least 2 TDs in 30 games, at least 3 TDs in 21 games, at least 4 TDs 11 times and at least 5 TDs 8 times (the only Trojan to have done so), including 4 times with a school record 6 TDs. He threw for at least 200 yards in 32 career games (a school record 15 times over 300 yards, as well as a school record 4 times over 400 yards). He had 47 career starts, more than any other USC quarterback (he was 34-13 as a starter).
He threw at least 2 TDs in 7 games in 2010 and at least 3 TDs 5 times, including twice with a school record-tying 5 TDs. His 236 completions in 2010 was eighth on the USC season list and his 2,774 yards of total offense was 11th on USC's season ladder. He was a semifinalist for the 2010 Davey O'Brien Award. He made 2010 All-Pac-10 honorable mention and Phil Steele All-Pac-10 third team. He was a USC captain, the first sophomore ever name a Trojan captain. He had surgery on his right wrist prior to 2010 spring practice to relieve stiffness and clean up inflammation.
He completed 78.3% of his passes (18-of-23) for 257 yards with a USC single game record-tying 5 TDs against Hawaii. He hit 20-of-35 passes for 202 yards and 2 TDs against Virginia and he also had a career-long 20-yard scramble. He was 17-of-26 for 192 yards and 2 TDs against Minnesota, but threw 2 interceptions (after beginning the 2010 season without a pick in his first 72 passes). He was 16-of-25 for 290 yards with 3 touchdowns at Washington State but threw 2 interceptions. He hit 70% of his passes (14-of-20) for 186 yards against Washington, but had his streak of games with a TD pass snapped at 12.
He completed 28-of-45 passes for 390 yards (all career highs) with 3 TDs against Stanford and he also tied for the team lead in rushing with 33 yards on 5 carries (with a career-long 27-yard scramble). He threw a USC single game record-tying 5 TDs (all in the first half, also tying a USC game record) against California and overall completed 25-of-37 passes for 352 yards as he earned College Football Performance Awards National Quarterback of the Week and Pac-10 Offensive Player of the Week honors. He was 26-of-49 for 264 yards with a TD against Oregon (it was the most pass attempts by a Trojan since Carson Palmer's 50 against Washington State in 2002), but he was picked off twice (to snap a streak of 140 passes without an interception) and lost a fumble; he also scored on a 1-yard sneak.
He was 26-of-37 for 215 yards and 3 TDs against Arizona State, but threw 2 interceptions (1 was returned for a TD and the other was in the end zone). He was 21-of-35 for 170 yards with a TD and an interception against Arizona (he was 15-of-20 for 124 yards in the first half) and also scored on a 1-yard sneak. He was 10-of-19 for 75 yards with an interception against Oregon State before being sidelined with an ankle sprain on USC's final play of the first half (the injury sidelined him for the next game against Notre Dame). He returned at UCLA and, playing with a high ankle sprain that sidelined him the previous game-and-a-half, completed 15-of-26 passes for 198 yards with 1 TD and 2 interceptions at UCLA.
He also had 2 short rushing touchdowns. His 211 completions put him 13th on USC's season passing list. He also was 12th on USC's season total offense list (2,697 yards). He was a semifinalist for the 2009 Davey O'Brien Award (he was the only freshman among the 15 semifinalists). He was named a 2009 CollegeFootballNews.com Freshman All-American honorable mention.
He completed 78.9% of his passes (15-of-19) for 233 yards with a touchdown and no interceptions against San Jose State as he became the first USC true freshman to ever start a season opener at quarterback (and the first true freshman quarterback to start an opener for an AP Top 5 team since No. 3 Michigan's Rick Leach did so in 1975), as well as just the third Trojan true freshman signalcaller to ever start a game (joining Rob Johnson, 1 start in 1991, and Carson Palmer, 5 starts in 1998).
He showed tremendous poise and leadership at noisy Ohio State as he completed 15-of-31 passes for 195 yards (with an interception) and led USC on a late 86-yard game-winning drive (contributing 55 passing yards and 2 sneaks for first downs in the series) despite bruising his throwing (right) shoulder in the second half, which sidelined him for the subsequent game at Washington.
He returned to the starting lineup against Washington State and hit 13-of-22 passes for 247 yards, with a pair of long touchdowns (29 and 57 yards), despite still somewhat bothered by a sore shoulder. He was 20-of-35 for 283 yards with an interception at California. He hit 19-of-29 passes for a career-best 380 yards with 2 touchdowns and an interception at Notre Dame (he was 11-of-14 for 234 yards in the second half, including completing 8 consecutive throws) to earn Davey O'Brien National Quarterback of the Week honors. He hit 15-of-25 passes for 202 yards with 2 TDs and 2 interceptions (and he also scored on a sneak) against Oregon State. He completed 21-of-38 passes for 187 yards and 2 short touchdowns at Oregon (his final pass was intercepted).
He was 7-of-22 for 112 yards with a TD (a 75-yarder, the longest at USC since a 93-yarder from Carson Palmer to Kareem Kelly in 2001 against Oregon) and an interception at Arizona State. He was 21-of-31 for 196 yards with 1 TD and 3 interceptions against Stanford. He was 18-of-26 for 206 yards with a 48-yard TD and an interception against UCLA. He was 20-of-37 for 144 yards with a TD and an interception against Arizona. He hit 73.0% of his passes (27-of-37, with a career high for completions) for 350 yards and 2 TDs, plus ran for a short TD, against Boston College.
As a junior in 2007, he was named the Gatorade Male High School Athlete of the Year and the Gatorade National Football Player of the Year (the first time a junior was ever selected for either honor), as well as winning Joe Montana Quarterback of the Year Award. He also made the 2007 USA Today All-USA second team, EA Sports All-American second team, Rivals.com Junior of the Year, Rivals.com Junior All-American first team, Cal-Hi Sports All-State first team, Cal-Hi Sports California Junior of the Year, Cal-Hi Sports All-State Underclass first team, All-CIF Pac-5 Division first team, Los Angeles Times All-Star Glenn Davis Award (as the top Southern California prep football player) and Orange County Register All-Orange County Offensive MVP.
He completed 213-of-340 passes (62.6%) for 3,576 yards (an Orange County record) and 35 TDs and 9 interceptions in 2007. As a sophomore in 2006, he made Cal-Hi Sports All-State Sophomore while passing for 1,349 yards and 11 TDs. A 4-year starter, he threw for 1,685 yards and 10 TDs as a 2005 freshman. Current Trojans Robbie Boyer (Barkley's cousin) and Khaled Holmes also prepped at Mater Dei.