Manning has been somewhat of a regular on the 'Late Show.' The reigning NFL MVP's first appearance with Letterman came almost 17 years ago when Manning was still in college. In December 1997, a 21-year-old Manning appeared on the 'Late Show' in the week leading up to the Heisman Trophy ceremony.
The May 5 show will mark Manning's fourth overall appearance with Letterman -- and it also could be his final one. Letterman announced on April 3 that he'll be retiring some time in the next year. Letterman's final show hasn't been officially scheduled yet, but it will come sometime in 2015.
On the other hand, the two could see each other again next February. Letterman has a long history of inviting Super Bowl winning quarterbacks to be guests on his show. That list includes Seahawks quarterback Russell Wilson, who went on the 'Late Show' in February after beating Manning in Super Bowl XLVIII.
So May 5 could be Peyton's final appearance on the 'Late Show,' but it might not be. Either way, you should plan to tune-in at 11:35 p.m. ET/PT on CBS.