| Passing | ||||
| CP/AT | YDS | TD | INT | |
| E. Manning | 26/40 | 311 | 2 | 2 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| B. Jacobs | 18 | 55 | 0 | 15 |
| D. Ware | 9 | 34 | 0 | 7 |
| E. Manning | 2 | 4 | 0 | 3 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| V. Cruz | 6 | 84 | 0 | 36 |
| M. Manningham | 6 | 77 | 1 | 18 |
| H. Nicks | 2 | 41 | 1 | 32 |
| J. Ballard | 3 | 35 | 0 | 17 |
| D. Ware | 5 | 34 | 0 | 10 |
| B. Pascoe | 2 | 23 | 0 | 14 |
| B. Jacobs | 2 | 17 | 0 | 16 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| Kicking | ||||
| FG | LG | XP | PTS | |
| L. Tynes | 2/2 | 25 | 2/2 | 8 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| S. Weatherford | 2 | 38.5 | 0 | 48 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| D. Scott | 2 | 26.5 | 0 | 37 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| V. Cruz | 3 | 4.0 | 0 | 11 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| K. Phillips | 4-1 | 0.0 | 0 | 0 |
| A. Rolle | 4-1 | 0.0 | 0 | 0 |
| G. Jones | 3-0 | 0.0 | 0 | 0 |
| A. Ross | 3-0 | 0.0 | 0 | 0 |
| M. Kiwanuka | 3-1 | 0.0 | 0 | 0 |
| C. Webster | 3-0 | 0.0 | 1 | 0 |
| J. Pierre-Paul | 2-0 | 0.0 | 0 | 0 |
| L. Joseph | 2-0 | 1.0 | 0 | 0 |
| M. Coe | 2-0 | 0.0 | 0 | 0 |
| S. Paysinger | 2-0 | 0.0 | 0 | 0 |
| O. Umenyiora | 2-0 | 1.0 | 0 | 0 |
| M. Boley | 2-1 | 0.0 | 0 | 0 |
| V. Cruz | 1-0 | 0.0 | 0 | 0 |
| C. Canty | 1-0 | 0.0 | 0 | 0 |
| D. Grant | 1-0 | 0.0 | 0 | 0 |
| T. Sash | 1-0 | 0.0 | 0 | 0 |
| D. Martin | 1-0 | 0.0 | 0 | 0 |
| B. Jacobs | 1-0 | 0.0 | 0 | 0 |
|
|
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| 4th Quarter | |
| New York at 2:46 | |
| 4-5-SF 42 | (2:46) (Shotgun) E.Manning pass short right to V.Cruz to SF 32 for 10 yards (C.Rogers). Caught at SF 32. 0-yds YAC |
| 1-10-SF 32 | (2:14) (Shotgun) D.Ware up the middle to SF 28 for 4 yards (P.Willis). |
| 2-6-SF 28 | (2:00) (Shotgun) E.Manning pass short right to D.Ware pushed ob at SF 18 for 10 yards (D.Goldson). Caught at SF 24. 6-yds YAC |
| 1-10-SF 18 | (1:53) (Shotgun) E.Manning pass short left to V.Cruz to SF 10 for 8 yards (D.Goldson). Caught at SF 10. 0-yds YAC |
| 2-2-SF 10 | (1:24) (Shotgun) E.Manning pass incomplete short left to M.Manningham. |
| 3-2-SF 10 | (1:19) (Shotgun) D.Ware up the middle to SF 10 for no gain (J.Smith). |
| 4-2-SF 10 | (:37) (Shotgun) E.Manning pass incomplete short middle to J.Ballard (J.Smith). |
| San Francisco at :34 | |
| 1-10-SF 10 | (:34) Alex Smith kneels to SF 9 for -1 yards. |
| 2-11-SF 9 | (:27) Alex Smith kneels to SF 8 for -1 yards. |
| 3-12-SF 8 | (:25) Alex Smith kneels to SF 7 for -1 yards. |
| 1st Quarter | ||
| FG | Lawrence Tynes, 23 Yd, 6:27. Drive: 14 plays, 75 yards in 8:33. | |
| FG | David Akers, 36 Yd, 0:25. Drive: 12 plays, 62 yards in 6:02. | |
| 2nd Quarter | ||
| FG | Lawrence Tynes, 25 Yd, 9:05. Drive: 13 plays, 73 yards in 6:20. | |
| FG | David Akers, 52 Yd, 5:00. Drive: 6 plays, 46 yards in 4:05. | |
| FG | David Akers, 39 Yd, 1:49. Drive: 7 plays, 32 yards in 3:11. | |
| 3rd Quarter | ||
| FG | David Akers, 28 Yd, 11:14. Drive: 10 plays, 70 yards in 3:46. | |
| TD | Mario Manningham, 13 Yd pass from Eli Manning (Lawrence Tynes kick is good), 2:25. Drive: 10 plays, 84 yards in 5:38. | |
| 4th Quarter | ||
| TD | Vernon Davis, 31 Yd pass from Alex Smith (Alex Smith pass to Michael Crabtree for 2 Pt. Conversion), 13:22. Drive: 4 plays, 50 yards in 1:59. | |
| TD | Kendall Hunter, 17 Yd run (David Akers kick is good), 12:21. Drive: 1 play, 17 yards in 0:05. | |
| TD | Hakeem Nicks, 32 Yd pass from Eli Manning (Lawrence Tynes kick is good), 8:37. Drive: 7 plays, 80 yards in 3:44. | |
| Passing | ||||
| CP/AT | YDS | TD | INT | |
| A. Smith | 19/30 | 242 | 1 | 1 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| K. Hunter | 6 | 40 | 1 | 17 |
| A. Smith | 6 | 27 | 0 | 14 |
| A. Dixon | 2 | 10 | 0 | 8 |
| F. Gore | 6 | 0 | 0 | 3 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| D. Walker | 6 | 69 | 0 | 19 |
| B. Edwards | 3 | 47 | 0 | 21 |
| V. Davis | 3 | 40 | 1 | 31 |
| T. Ginn | 3 | 39 | 0 | 16 |
| M. Crabtree | 1 | 21 | 0 | 21 |
| K. Williams | 1 | 14 | 0 | 14 |
| F. Gore | 1 | 8 | 0 | 8 |
| K. Hunter | 1 | 4 | 0 | 4 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| Kicking | ||||
| FG | LG | XP | PTS | |
| D. Akers | 4/4 | 52 | 1/1 | 13 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| A. Lee | 3 | 54.7 | 1 | 57 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| T. Ginn | 2 | 27.5 | 0 | 31 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| Defense | ||||
| T-A | SCK | INT | FF | |
| N. Bowman | 11-4 | 0.0 | 0 | 0 |
| P. Willis | 9-2 | 1.0 | 0 | 0 |
| D. Whitner | 7-0 | 0.0 | 0 | 0 |
| C. Rogers | 5-1 | 0.0 | 2 | 0 |
| J. Smith | 5-1 | 0.0 | 0 | 0 |
| D. Goldson | 4-0 | 0.0 | 0 | 0 |
| R. McDonald | 3-0 | 0.0 | 0 | 0 |
| P. Haralson | 2-0 | 0.0 | 0 | 0 |
| T. Brown | 2-1 | 0.0 | 0 | 0 |
| I. Sopoaga | 2-1 | 0.0 | 0 | 0 |
| A. Brooks | 2-2 | 0.0 | 0 | 0 |
| C. Culliver | 1-1 | 0.0 | 0 | 0 |
| C. Spillman | 1-0 | 0.0 | 0 | 0 |
| L. Grant | 1-0 | 0.0 | 0 | 0 |
| D. Akers | 1-0 | 0.0 | 0 | 0 |
| T. Ginn | 1-0 | 0.0 | 0 | 0 |
| C. Jones | 1-0 | 0.0 | 0 | 0 |
| A. Smith | 0-2 | 0.0 | 0 | 0 |
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