| Passing | ||||
| CP/AT | YDS | TD | INT | |
| C. Kaepernick | 16/25 | 231 | 1 | 1 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| F. Gore | 19 | 83 | 0 | 14 |
| K. Hunter | 4 | 28 | 0 | 21 |
| C. Kaepernick | 6 | 27 | 1 | 15 |
| A. Dixon | 1 | 5 | 0 | 5 |
| B. Jacobs | 1 | 1 | 0 | 1 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| D. Walker | 3 | 81 | 0 | 45 |
| M. Manningham | 5 | 69 | 0 | 40 |
| B. Miller | 3 | 37 | 0 | 26 |
| M. Crabtree | 3 | 26 | 0 | 15 |
| F. Gore | 2 | 18 | 1 | 12 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| T. Ginn | 1 | 1 | 0 | 0 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| D. Akers | 1/3 | 27 | 4/4 | 7 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| A. Lee | 4 | 46.8 | 2 | 59 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| K. Williams | 1 | 23.0 | 0 | 23 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| T. Ginn | 2 | 6.5 | 0 | 13 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| P. Willis | 7-3 | 0.5 | 0 | 0 |
| D. Whitner | 5-3 | 0.0 | 1 | 0 |
| A. Smith | 4-1 | 1.5 | 0 | 0 |
| A. Brooks | 4-1 | 1.5 | 1 | 0 |
| T. Brown | 3-1 | 0.0 | 0 | 0 |
| D. Goldson | 3-3 | 0.0 | 0 | 0 |
| N. Bowman | 3-3 | 0.0 | 0 | 0 |
| J. Smith | 2-2 | 1.5 | 0 | 0 |
| C. Culliver | 2-1 | 0.0 | 0 | 0 |
| R. McDonald | 2-0 | 0.0 | 0 | 0 |
| D. Walker | 1-0 | 0.0 | 0 | 0 |
| T. Gooden | 1-0 | 0.0 | 0 | 0 |
| I. Sopoaga | 1-1 | 0.0 | 0 | 0 |
| K. Williams | 1-0 | 0.0 | 0 | 0 |
| R. Jean Francois | 1-1 | 0.0 | 0 | 0 |
| C. Spillman | 1-0 | 0.0 | 0 | 0 |
| T. Brock | 1-0 | 0.0 | 0 | 0 |
| T. Ginn | 1-0 | 0.0 | 0 | 0 |
| P. Cox | 1-0 | 0.0 | 0 | 0 |
| B. Miller | 1-0 | 0.0 | 0 | 0 |
| 1 | 2 | 3 | 4 | |
| San Francisco | 7 | 7 | 14 | 3 |
| New Orleans | 7 | 7 | 7 | 0 |
| 1st Quarter | ||
| TD @ 7:21 | Colin Kaepernick runs for 7 yards (David Akers kick is good). Drive: 4 plays, 62 yards in 2:06. | |
| TD @ 1:45 | David Thomas catches a 6 yard pass from Drew Brees (Garrett Hartley kick is good). Drive: 10 plays, 79 yards in 5:36. | |
| 2nd Quarter | ||
| TD @ 7:53 | Marques Colston catches a 10 yard pass from Drew Brees (Garrett Hartley kick is good). Drive: 2 plays, 11 yards in 0:48. | |
| TD @ 0:22 | Ahmad Brooks makes a 50 yard interception return (David Akers kick is good). | |
| 3rd Quarter | ||
| TD @ 12:17 | Frank Gore catches a 6 yard pass from Colin Kaepernick (David Akers kick is good). Drive: 6 plays, 80 yards in 2:43. | |
| TD @ 11:30 | Donte Whitner makes a 42 yard interception return (David Akers kick is good). | |
| TD @ 7:19 | Jed Collins catches a 2 yard pass from Drew Brees (Garrett Hartley kick is good). Drive: 8 plays, 80 yards in 4:11. | |
| 4th Quarter | ||
| FG @ 7:50 | David Akers makes a 27 yard kick. Drive: 16 plays, 85 yards in 9:28. | |
| 4th Quarter | |
| 2-8-NO 10 | (2:20) F.Gore left tackle for 10 yards, TOUCHDOWN NULLIFIED by Penalty. PENALTY on SF-M.Iupati, Offensive Holding, 10 yards, enforced at NO 10 - No Play. |
| 2-18-NO 20 | (2:14) B.Jacobs left tackle to NO 19 for 1 yard (J.Vilma). |
| 3-17-NO 19 | (2:00) F.Gore right tackle to NO 15 for 4 yards (D.Hawthorne; C.Lofton). |
| 4-13-NO 15 | (1:13) D.Akers 33 yard field goal is BLOCKED (M.Jenkins), Center-B.Jennings, Holder-A.Lee, RECOVERED by NO-M.Jenkins at NO 22. PENALTY on NO-B.Bunkley, Personal Foul, 11 yards, enforced at NO 22. NO #77 B.Bunkley was disqualified from the game. |
| 1-10-NO 11 | (1:05) (Shotgun) D.Brees pass incomplete deep right to D.Henderson. |
| 2-10-NO 11 | (1:00) (Shotgun) D.Brees pass incomplete short left to D.Sproles. |
| 3-10-NO 11 | (:56) (Shotgun) D.Brees pass short right to J.Graham to NO 19 for 8 yards (N.Bowman). Pass 8, YAC 0 |
| 4-2-NO 19 | (:31) (Shotgun) D.Brees pass short middle to J.Graham to NO 28 for 9 yards (P.Willis). Pass 6, YAC 3 |
| 1-10-NO 28 | (:13) (Shotgun) D.Brees pass short left to D.Sproles ran ob at SF 37 for 35 yards (T.Brown). Pass -1, YAC 36 |
| 1-10-SF 37 | (:04) D.Brees kneels to SF 38 for -1 yards. |
| Passing | ||||
| CP/AT | YDS | TD | INT | |
| D. Brees | 26/41 | 267 | 3 | 2 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| C. Ivory | 8 | 34 | 0 | 7 |
| M. Ingram | 10 | 27 | 0 | 7 |
| P. Thomas | 1 | 0 | 0 | 0 |
| D. Brees | 2 | -2 | 0 | -1 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| D. Sproles | 7 | 65 | 0 | 35 |
| L. Moore | 3 | 61 | 0 | 43 |
| M. Colston | 4 | 36 | 1 | 13 |
| J. Morgan | 1 | 33 | 0 | 33 |
| J. Graham | 4 | 33 | 0 | 12 |
| D. Thomas | 4 | 24 | 1 | 9 |
| J. Collins | 2 | 9 | 1 | 7 |
| D. Henderson | 1 | 6 | 0 | 6 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| R. Bush | 0 | 0 | 1 | 0 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| G. Hartley | 0/0 | 0 | 3/3 | 3 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| T. Morstead | 5 | 50.4 | 2 | 56 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| T. Cadet | 5 | 29.6 | 0 | 36 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| D. Sproles | 1 | 3.0 | 0 | 3 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| M. Jenkins | 4-3 | 0.0 | 0 | 0 |
| C. Jordan | 4-1 | 0.0 | 0 | 0 |
| C. Lofton | 4-5 | 0.0 | 0 | 0 |
| I. Abdul-Quddus | 3-1 | 0.0 | 0 | 0 |
| J. Greer | 3-2 | 0.0 | 0 | 0 |
| R. Harper | 2-5 | 0.0 | 0 | 0 |
| W. Smith | 2-4 | 0.0 | 0 | 0 |
| J. Vilma | 2-2 | 0.0 | 0 | 0 |
| J. Casillas | 1-0 | 0.0 | 0 | 0 |
| S. Ellis | 1-4 | 0.0 | 0 | 0 |
| P. Robinson | 1-1 | 0.0 | 1 | 0 |
| D. Hawthorne | 1-5 | 0.0 | 0 | 0 |
| T. Johnson | 0-3 | 0.0 | 0 | 0 |
| B. Bunkley | 0-1 | 0.0 | 0 | 0 |
| A. Hicks | 0-1 | 0.0 | 0 | 0 |
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