Clowney had a season-high eight tackles (seven solo), including four for losses on running plays, in Houston's 31-13 loss to Minnesota. He also flushed quarterback Sam Bradford out of the pocket twice.
This may have been Clowney's best overall game since he entered the NFL in 2014. And he needs to be at his best now that J.J. Watt (back) it out of action.
Johnson (foot) will be placed on IR and is out for the remainder of the season, Aaron Wilson of the Houston Chronicle reports.
Johnson broke his foot in Sunday's game but missed just one play, playing much of the second half with the injury. It isn't yet clear if he'll need surgery or let the injury heal on its own but either way the team will likely place him on IR in the near future. Robert Nelson and A.J. Bouye figure to see extra time with Johnson out.
Simon recorded six tackles, three quarterback hits and 1.5 sacks in Houston's win over Kansas City in Week 2. He's recorded sacks in each of the first two games.
Simon, who had 5.0 sacks in 2015, made some big plays during preseason, forcing the coaching staff to find a spot for him in the starting lineup. As such, defensive coordinator Romeo Crennel moved Jadeveon Clowney to defensive end in order to get Simon on the field.
Demps (calf) sat out practice Thursday, Aaron Wilson of the Houston Chronicle reports.
Demps missed all of last week's practices due to his calf injury before being ruled out for Week 6. If he's unable to practice the rest of the week it seems unlikely that he'd be able to play in Week 7. Corey Moore got the start in Week 6 and will likely continue to see extra time while Demps is out.
Fuller (hamstring) will play Monday night against the Broncos, ESPN's Sarah Barshop reports.
Fuller was active last weekend, but ended up not playing against the Colts due to his hamstring. Since then, he's apparently made enough strides in practice for coach Bill O'Brien to confirm his status in advance of Monday's kickoff. While that clarity helps fantasy owners in timing their decision-making, Fuller's matchup with Denver's vaunted secondary should've tempered expectations of him even if he wasn't a bit banged-up.
Martin (hamstring) has been ruled out for Sunday's game in San Francisco.
Martin was seemingly on track to practice for the first time since he injured his hamstring in Week 2, but he then suffered a setback at some point last week, leaving him without a clear timetable to return. With Charles Sims (knee) also out of the picture, Jacquizz Rodgers is set to handle a heavy three-down workload in Sunday's favorable matchup against the leaky San Francisco run defense. Peyton Barber and Antone Smith will provide depth.
McDonald (hamstring) will not play against the 49ers on Sunday.
McDonald was able to return to practice after sitting out on Wednesday, but will be held out due to the lingering nature of hamstring injuries. However, he appears to have an optimistic chance of returning next week. Akeem Spence will get the start on Sunday as his replacement.
Shorts (hamstring) is listed as questionable for Sunday's game against the 49ers.
Shorts has been sidelined since Week 2 due to a hamstring ailment, but that problem looks to be behind him given his increased activity level this week. If Shorts is indeed able to return Sunday, his matchup with the 49ers and teammate Vincent Jackson's (knee) absence could help him improve on his lone catch for 12 yards this season.
James (undisclosed) reached an injury settlement with the Buccaneers on Wednesday, ESPN reports.
Following a three-year stint with the Bucs, the team decided to part ways with James due to a vague injury he can't seem to overcome. In the wake of his release, Tampa Bay promoted rookie Peyton Barber from the practice squad and plucked Jacquizz Rodgers off the free agent market.
Bell (concussion) reached an injury settlement with the Buccaneers on Thursday, Aaron Wilson of the Houston Chronicle reports.
Bell suffered a concussion in Week 4's preseason finale against the Redskins, leaving him on the sidelines for an extended amount of time. The team decided to part ways with wideout instead of holding him on IR for the year.