Bradham left Sunday's loss to Kansas City due to an ankle injury and was seen in a walking boot leaving the locker room, The Buffalo News reports.
Bradham managed just four total tackles with no other stats prior to leaving, so his day was pretty poor for IDP owners. As for the Buffalo defense, Preston Brown and Bradham are the best two linebackers amid a corps without much experience, so if Bradham has to miss any time it's going to be felt by a Buffalo defense that's already down several key players.
Carrington tore his quad tendon during Sunday's loss to the Chiefs and now requires season-ending surgery, NFL.com's Ian Rapoport reports.
Carrington surprisingly found himself in the Bills' starting lineup Sunday in wake of injuries to teammates, but it appears he's suffered the same fate, as his quad ailment will cost him the rest of this season. Knowing that, Carrington finishes the campaign with eight tackles in seven appearances.
Williams is slated to undergo season-ending left knee surgery, ESPN.com reports.
Williams, who hasn't played since Oct. 18, has been slow to recover from a meniscus injury and will thus turn to a procedure that should enable him to return to the playing field well in advance of the 2016 season.
Matthews looks iffy for Sunday's game against the Ravens because of what the Miami Herald describes as cracked ribs.
With Matthews limited to just three snaps this past Sunday, rookie DeVante Parker stepped in to log 58 Week 12 snaps, a trend that seems likely to continue this coming weekend, given Matthews' decidedly cloudy status.