Jefferson (thumb) was a full participant in Wednesday's practice, John Boyle of the Seahawks' official site reports.
Jefferson previously required surgery to repair a thumb injury and had been slotted for a Week 7 return. Now practicing without restraint, it appears said prediction will prove accurate, barring a setback in practice this week.
Rawls (ankle) remains a few weeks away from his return, according to coach Pete Carroll, 710 ESPN Seattle's Liz Mathews reports.
Rawls has been sidelined since Week 2 due to a fibula injury and general manager John Schneider started October by projecting he'd need another month to recover. As a result, Carroll saying he's still a few weeks away fits that timeline, although Rawls still has no definitive date for his expected return. While that leaves his already-frustrated fantasy owners in further limbo, Rawls' absence figures to allow Christine Michael to continue to dominate Seattle's backfield workload, with rookie Alex Collins and C.J. Prosise (wrist) factoring in behind him.
Willson (knee - MCL) responded well to surgery and is hopeful to return this season, ESPN's Liz Mathews reports.
Willson injured his knee Sunday against the Falcons and went under the knife Tuesday in order to fix it. He's slated to miss multiple games, but it seems he could realistically return later on in the season.
Hyde (shoulder) has been ruled out for Sunday's game against Tampa Bay.
As expected, the 49ers' workhorse will miss at least one game, leaving the team's backfield in the hands of Mike Davis and Shaun Draughn, with DuJuan Harris getting a call up from the practice squad. Hyde doesn't believe the injury is a long-term concern, and with the 49ers on bye in Week 8, it's quite possible he'll only miss the one game. Davis is the favorite to lead the team in carries on Sunday, after replacing Draughn as the No. 2 running back in last week's loss to the Bills. Draughn is still the favorite for passing-down work, and he could also end up getting more carries if he outplays Davis early in the game.
Smith (back) is listed as questionable for Sunday's game against Tampa Bay.
A mid-week addition to Thursday's injury report, Smith still managed to log limited practices both Thursday and Friday. His participation in any capacity suggests he should be able to play, but if not, Rod Streater and/or Aaron Burbridge would join Quinton Patton and Jeremy Kerley in three-wide sets. Even in a favorable matchup, the San Francisco passing game offers little cause for excitement.
Smelter (hamstring) was added to the 49ers' practice squad, Matt Maiocco of CSN Bay Area reports.
Smelter was cut by the 49ers prior to the season after suffering a hamstring injury during training camp. Prior to the injury, the 2015 fourth-round pick had light breakout potential due to his size and athleticism. It is unclear if and when the 49ers will give Smelter a chance on the 53-man roster, or even if his hamstring injury has fully healed. While he is definitely not a player worth picking up right now, there is still potential for a late-season appearance where the team tries to get a better look at their former top receiving prospect on a team devoid of reliable options at that position.