Wentz (ribs) will not play in Saturday's matchup with the Colts.
Wentz suffered a hairline rib fracture in the preseason opener and hasn't taken the field since. His final chance to return will be on Sept. 1 in the final preseason game against the Jets. With Wentz out, Sam Bradford has cemented his role as the Eagles' starting quarterback this preseason and should see a majority of the reps on Saturday night.
Matthews, who suffered a bone bruise on his left knee back on Aug. 5, plans to be ready to play in advance of Week 1, the Philadelphia Inquirer reports. "I promise you I'll be ready for the first game," Matthews declared Tuesday. "I don't like to put percentages on anything, but at the same time, I'm definitely feeling good. I'm doing a lot better. I'm running around, moving, lifting, jumping. I'm back doing pretty much all of that stuff."
Matthews, who is coming off a 2015 campaign in which he caught 85 passes for 997 yards and eight touchdowns, doesn't seem likely to see any preseason action, but the goal here is exercise a degree of patience and caution, with having the wideout available for the Eagles' Sept. 11 contest against the Browns. Upon his return to action, Matthews is set to serve as the team's top wideout, with Nelson Agholor, Dorial Green-Beckham, Rueben Randle, Josh Huff, Chris Givens and Paul Turner all still jostling for slotting on Philadelphia's wideout depth chart.
Smallwood (quadriceps) is slated to take the field for Saturday's preseason game at Indianapolis, Jeff McLane of the Philadelphia Inquirer reports.
Smallwood missed back-to-back contests to kick off exhibition season, but increasing his workload little by little for two weeks will seemingly yield an appearance Saturday. A cautious approach is expected, though, as the running back's quad continues to heal. All but guaranteed a roster spot due to his status as a 2016 fifth-round selection, he could be relegated to weekly inactives in-season with Ryan Mathews, Darren Sproles, and Kenjon Barner all positioned ahead of Smallwood on the depth chart.
Head coach Bruce Arians told Josh Weinfuss of ESPN.com on Thursday that Nkemdiche (ankle) put in a "good day" at Wednesday's practice. "I thought the 1-on-1s were good," Arians said. "I thought the team periods, he was still a little bit high at times. He's obviously got pass-rush ability."
Contained to individual drills Monday, Nkemdiche was reticent to practice Wednesday due to lingering soreness in his ankle, but upon some prodding from Arians, the rookie defensive lineman gutted out individual and seemingly even some team work. Nkemdiche has time to prove his health in advance of Sunday's exhibition at Houston, but a DNP may be the prudent approach if there's any question surrounding the ankle.
Fitzgerald (knee) wasn't expected to practice Thursday but was seen in pads prior to drills, Josh Weinfuss of ESPN.com reports.
Fitzgerald may have been able to change the mind of head coach Bruce Arians, who has been the driving force behind holding out the wide receiver as he tends to a slight MCL sprain. Individual drills would be a good start Thursday, but there's no need for Fitzgerald to push his luck with more than two weeks remaining before the regular season opener.
Okafor has opted to avoid surgery and play with a torn biceps, Ian Rapoport of NFL Network reports.
Okafor sustained the injury in Tuesday's practice, the second such torn biceps in his three-year career. In 2013, surgery was ordered up for the then rookie, but examinations may have revealed that the tear was less severe than three seasons ago. The pass rusher has totaled 10 sacks the past two campaigns, while logging 66 and 58.5 percent of the defensive snaps, but the addition of Chandler Jones along with the injury could very well result in a scaled-back role.
Brown (concussion) was removed from practice early Thursday, Josh Weinfuss of ESPN.com reports.
One day removed from missing practice due to a headache, Brown took the field Thursday in a no-contact yellow jersey, as he did both Sunday and Monday of this week. While his early departure may have been planned, the fact that his symptoms can be traced to a concussion doesn't bode well for immediate clearance from the NFL's protocol for head injuries.
Jenkins (hand) returned to practice on Sunday, Mike Jurecki of Fox Sports 910 reports.
Jenkins had surgery for a broken hand at the start of August. He was expected to miss anywhere from 2-to-3 weeks, so his return Sunday appears to be on the early side of that original projection. Jenkins will have to battle for a role as a depth option at cornerback for the upcoming season.