With Ayers out for a second straight week, George Selvie will likely slide over to left defensive end again, allowing Kerry Wynn to join the starting lineup as the right defensive end. Even against a run-heavy Bills team, the Giants defense will sorely miss its most effective pass-rusher.
Giants wide receiver Victor Cruz (calf) won't play Sunday against the 49ers, but he is aiming to return Week 6 against the Eagles, the New York Daily News reports.
Cruz is slated for an examination with team doctors Monday, which is 10 days removed from receiving a PRP injection in his left calf. After he meets with the doctors, he'll adjust his timetable for a return to running, according to The Record.
With a Monday night contest in Week 6, Cruz will have an extra day to prove the health of the calf. However, next Thursday's practice will ultimately set the groundwork for the potential to make his season debut.
George Selvie will be reunited with former University of South Florida teammate Jason Pierre-Paul in New York. The defensive lineman signed a one-year, $1.4 million deal with the Giants that includes a $200,000 signing bonus, according to Adam Schefter of ESPN.
Three injured players have been placed on the inactive list by the Patriots for their season opener Thursday night against Pittsburgh. They are running back Travaris Cadet (hamstring), defensive lineman Trey Flowers (knee) and safety Tavon Wilson (quad).