With Ayers out for a second straight week, George Selvie will likely slide over to left defensive end again, allowing Kerry Wynn to join the starting lineup as the right defensive end. Even against a run-heavy Bills team, the Giants defense will sorely miss its most effective pass-rusher.
Giants wide receiver Victor Cruz (calf) won't play Sunday against the 49ers, but he is aiming to return Week 6 against the Eagles, the New York Daily News reports.
Cruz is slated for an examination with team doctors Monday, which is 10 days removed from receiving a PRP injection in his left calf. After he meets with the doctors, he'll adjust his timetable for a return to running, according to The Record.
With a Monday night contest in Week 6, Cruz will have an extra day to prove the health of the calf. However, next Thursday's practice will ultimately set the groundwork for the potential to make his season debut.
Giants linebacker Devon Kennard (hamstring) has been ruled out for the game Sunday against the 49ers.
Kennard is off to an impressive start, with 25 tackles (15 solo) and an interception in four games. The Giants still don't have an every-down linebacker, but Kennard leads the group in snaps. In his absence, Mark Herzlich could get the start, though a bunch of players may benefit from added snaps.
George Selvie will be reunited with former University of South Florida teammate Jason Pierre-Paul in New York. The defensive lineman signed a one-year, $1.4 million deal with the Giants that includes a $200,000 signing bonus, according to Adam Schefter of ESPN.
Panthers linebacker Luke Kuechly will meet with an independent doctor again this week in hopes of being cleared from the NFL's concussion protocol, The Charlotte Observer reports.
Kuechly has been sidelined since Week 1 due to a concussion and despite entering the final stage of league protocol last week, he was unable to receive clearance from an independent doctor ahead of Sunday's game versus the Buccaneers.
Now with the Panthers on their bye week, Kuechly will hope to be given the green light to return in the coming days and reclaim his starting position for Carolina's Week 6 game against the Seahawks.