McCluster will be out for 2-3 weeks due to his knee injury suffered during Thursday's game.
McCluster took a hard hit to his knee during Thursday's loss to the Jaguars, which will force him to miss the Titans' next couple games or so. With him out, Antonio Andrews will likely enjoy an expanded role, while rookie David Cobb and Bishop Sankey also factor into the mix.
The Titans signed defensive lineman Al Woods to a two-year deal Wednesday, ending his two-year run with the Steelers. Woods' contract will pay him $5 million over two years, according to the Pittsburgh Post-Gazette.
Wreh-Wilson (hamstring) is inactive for Thursday's game against the Jaguars.
With Wreh-Wilson out and Jason McCourty now on IR, the Titans' secondary is banged up in advance of Thursday's game, but fortunately for the team, fellow cornerback Perrish Cox is back in the mix this week, after sitting out Week 10's action.
Titans head coach Mike Mularkey expects Wright (knee) to return for Sunday's game against the Raiders, TitanInsider.com's Terry McCormick reports.
Wright missed the past three games, allowing a few different players to see extra targets. Delanie Walker took advantage and will remain a crucial piece of the Tennessee passing game, but none of the wideouts made a strong impression. Despite the early optimism, Wright likely still needs to prove his health during practice.
Irvin (knee) is inactive Sunday against the 49ers.
Irvin (knee) was listed as out earlier in the week, so this news comes as no surprise. Expect both Mike Morgan and Kevin Pierre-Louis to take over duties at strong side linebacker in Irvin's absence. The Seattle defense should be just fine without him at home against the 49ers offense.
Lynch underwent sports hernia surgery Wednesday and will be out three to four weeks, the Seattle Times reports.
Coach Pete Carroll didn't rule out that Lynch could be done for the season, but he said doctors were "very optimistic" that they fixed the issue and that Lynch can return quickly. Thomas Rawls will start while Lynch is out.
Richardson (hamstring) has been ruled out for Sunday's game against the 49ers.
Richardson made his first appearance of the season Sunday against the Cardinals, hauling in a 40-yard pass on his only target. His good fortune didn't last long, as he suffered a hamstring injury on the play and stumbled before reaching the end zone. Even when healthy, Richardson probably won't get enough snaps to warrant fantasy consideration.