Bills quarterback EJ Manuel left the game with a knee injury in the third quarter on Thursday. (USATSI)
Bills quarterback EJ Manuel left the game with a knee injury in the third quarter on Thursday. (USATSI)

It's been a rough night for quarterbacks in Cleveland.

Browns starter Brian Hoyer was knocked out of the game in the first quarter after sliding awkwardly after an 11-yard run. Hoyer's injury could be serious, Browns coach Rob Chudzinski said the team is fearful that Hoyer has a torn ligament. 

Hoyer isn't the only injured quarterback though. Bills starter EJ Manuel left the game in the third quarter after taking a big hit from Browns defensive back Tashaun Gipson. Manuel grabbed his right knee after the play and left the game. He did not return.

The injury happened on a third-and-8 play as Manuel was finishing a 14-yard scramble. Manuel was near the sideline but wasn't out of bounds when Gipson hit him. Manuel immediately clutched his right knee after the hit.

Manuel was able to walk off the field under his own power. 

The Bills backup quarterback is undrafted free agent Jeff Tuel. Tuel entered the game with 8:02 left in the third quarter and finished the touchdown drive that Manuel started to give Buffalo a 24-17 lead.