Titans open 2.5 favorites over the Colts

The Tennessee Titans have opened up as 2.5 favorites over the Indianapolis Colts in advance of Sunday's AFC South matchup at Nissan Stadium.

The Titans are coming off a 28-26 win over the Cleveland Browns. The Colts are coming off a 26-23 overtime loss to the Houston Texans on Sunday.

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The Colts have won the last nine games in the series. The Colts won 35-33 in Nashville and 30-24 in Indianapolis last season.

The Colts lead the overall series 29-14 between the two franchises. 

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