Hyde, Johnson and Brock were all ruled out for Saturday's game on the team's final report, but Brooks joins them on the inactive list after being deemed questionable. The team will have running back Frank Gore and wide receiver Michael Crabtree active for the game.
The 49ers are a 1-point favorite for the Saturday night showdown with the Chargers.
"I’m approaching training camp as a time to compete and get better, and I want to show the coaches I’m getting better every day," Looney said. "Alex Boone is a hell of a player and a hell of a guy, and him being gone is his business. But watching him on film every day, I want to come in and do a hell of a job like he does."
Coach Jim Harbaugh praised Looney's performance so far.
Rogers attempted to practice throughout the week, but was questionable. He will not play. The other six players are healthy scratches.
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