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| NFL Sacks | ||||
| Rank | Player | Team | Sacks | Tackles |
| 1 | Elvis Dumervil | DEN | 17 | 49 |
| 2 | Jared Allen | MIN | 14.5 | 51 |
| 3 | Dwight Freeney | IND | 13.5 | 24 |
| 4 | LaMarr Woodley | PIT | 13.5 | 62 |
| 5 | Will Smith | NO | 13 | 49 |
| 6 | Trent Cole | PHI | 12.5 | 57 |
| 7 | DeMarcus Ware | DAL | 11 | 57 |
| 8 | Andre Carter | WAS | 11 | 62 |
| 9 | Brian Orakpo | WAS | 11 | 50 |
| 10 | Julius Peppers | CAR | 10.5 | 42 |
| 11 | Aaron Schobel | BUF | 10 | 56 |
| 12 | Tully Banta-Cain | NE | 10 | 55 |
| 13 | James Harrison | PIT | 10 | 79 |
| 14 | Clay Matthews | GB | 10 | 51 |
| 15 | Robert Mathis | IND | 9.5 | 37 |
| 16 | Joey Porter | MIA | 9 | 41 |
| 17 | Mario Williams | HOU | 9 | 43 |
| 18 | Tamba Hali | KC | 8.5 | 62 |
| 19 | Ray Edwards | MIN | 8.5 | 51 |
| 20 | Calvin Pace | NYJ | 8 | 55 |
| 21 | Antwan Odom | CIN | 8 | 19 |
| 22 | Juqua Parker | PHI | 8 | 34 |
| 23 | Randy Starks | MIA | 7 | 56 |
| 24 | Jason Taylor | MIA | 7 | 42 |
| 25 | Lawrence Timmons | PIT | 7 | 78 |
| 26 | Greg Ellis | OAK | 7 | 29 |
| 27 | Trevor Scott | OAK | 7 | 43 |
| 28 | Shaun Phillips | SD | 7 | 59 |
| 29 | Osi Umenyiora | NYG | 7 | 29 |
| 30 | Calais Campbell | ARI | 7 | 48 |
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