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| NFL Sacks | ||||
| Rank | Player | Team | Sacks | Tackles |
| 1 | Aldon Smith | SF | 3.5 | 19 |
| 2 | Darryl Richard | NE | 3 | 5 |
| 3 | Von Miller | DEN | 3 | 9 |
| 4 | Vaughn Martin | SD | 3 | 8 |
| 5 | Jacquian Williams | NYG | 3 | 14 |
| 6 | Phillip Hunt | PHI | 3 | 7 |
| 7 | George Johnson | TB | 3 | 10 |
| 8 | Amobi Okoye | CHI | 3 | 7 |
| 9 | Adrian Awasom | MIN | 3 | 7 |
| 10 | Dwight Freeney | IND | 2.5 | 4 |
| 11 | Aaron Maybin | NYJ | 2.5 | 5 |
| 12 | Lazarius Levingston | SEA | 2.5 | 7 |
| 13 | Brian Rolle | PHI | 2.5 | 10 |
| 14 | Vic So'oto | GB | 2.5 | 13 |
| 15 | Dekoda Watson | TB | 2.5 | 11 |
| 16 | Bryan Braman | HOU | 2.5 | 10 |
| 17 | Danny Batten | BUF | 2 | 11 |
| 18 | Marcell Dareus | BUF | 2 | 3 |
| 19 | Robert Eddins | BUF | 2 | 11 |
| 20 | Shawne Merriman | BUF | 2 | 6 |
| 21 | Philip Wheeler | IND | 2 | 22 |
| 22 | Ryan Baker | MIA | 2 | 9 |
| 23 | Jason Trusnik | MIA | 2 | 11 |
| 24 | Niko Koutouvides | NE | 2 | 5 |
| 25 | Jerod Mayo | NE | 2 | 13 |
| 26 | Garrett McIntyre | NYJ | 2 | 9 |
| 27 | Josh Bynes | BAL | 2 | 12 |
| 28 | Paul Kruger | BAL | 2 | 8 |
| 29 | Scott Paxson | CLE | 2 | 5 |
| 30 | Nate Collins | JAC | 2 | 9 |
