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| NFL Sacks | ||||
| Rank | Player | Team | Sacks | Tackles |
| 1 | Jared Allen | MIN | 22.0 | 66 |
| 2 | DeMarcus Ware | DAL | 19.5 | 58 |
| 3 | Jason Babin | PHI | 18.0 | 40 |
| 4 | Jason Pierre-Paul | NYG | 16.5 | 86 |
| 5 | Terrell Suggs | BAL | 14.0 | 70 |
| 6 | Aldon Smith | SF | 14.0 | 37 |
| 7 | Chris Long | STL | 13.0 | 37 |
| 8 | Tamba Hali | KC | 12.0 | 66 |
| 9 | Connor Barwin | HOU | 11.5 | 47 |
| 10 | Von Miller | DEN | 11.5 | 64 |
| 11 | Cliff Avril | DET | 11.0 | 36 |
| 12 | Chris Clemons | SEA | 11.0 | 51 |
| 13 | Trent Cole | PHI | 11.0 | 45 |
| 14 | Antwan Barnes | SD | 11.0 | 41 |
| 15 | Julius Peppers | CHI | 10.5 | 37 |
| 16 | Mark Anderson | NE | 10.0 | 29 |
| 17 | Andre Carter | NE | 10.0 | 52 |
| 18 | John Abraham | ATL | 9.5 | 35 |
| 19 | Elvis Dumervil | DEN | 9.5 | 42 |
| 20 | Robert Mathis | IND | 9.5 | 43 |
| 21 | Charles Johnson | CAR | 9.0 | 41 |
| 22 | Brian Orakpo | WAS | 9.0 | 59 |
| 23 | James Harrison | PIT | 9.0 | 59 |
| 24 | LaMarr Woodley | PIT | 9.0 | 39 |
| 25 | Osi Umenyiora | NYG | 9.0 | 25 |
| 26 | Dwight Freeney | IND | 8.5 | 19 |
| 27 | Jabaal Sheard | CLE | 8.5 | 55 |
| 28 | Cameron Wake | MIA | 8.5 | 42 |
| 29 | Kyle Vanden Bosch | DET | 8.0 | 35 |
| 30 | Brian Robison | MIN | 8.0 | 44 |
