| Passing | |||||||
| Name | Team | Comp | Att | Yds | TDs | Ints | |
| 1. Ben Roethlisberger, QB | PIT | 36 | 49 | 384 | 4 | 0 | |
| 2. Joe Flacco, QB | BAL | 28 | 39 | 382 | 3 | 1 | |
| 3. Jake Locker, QB | TEN | 29 | 42 | 378 | 2 | 0 | |
| 4. Tom Brady, QB | NE | 28 | 41 | 335 | 1 | 0 | |
| 5. Peyton Manning, QB | DEN | 26 | 52 | 330 | 2 | 0 | |
| 6. Andy Dalton, QB | CIN | 19 | 27 | 328 | 3 | 1 | |
| 7. Andrew Luck, QB | IND | 22 | 46 | 313 | 2 | 1 | |
| 8. Mark Sanchez, QB | NYJ | 21 | 45 | 306 | 1 | 2 | |
| 9. Matt Schaub, QB | HOU | 17 | 30 | 290 | 4 | 1 | |
| 10. Eli Manning, QB | NYG | 27 | 35 | 288 | 1 | 0 | |
| 11. Tony Romo, QB | DAL | 25 | 39 | 283 | 0 | 1 | |
| 12. Matthew Stafford, QB | DET | 33 | 42 | 278 | 1 | 0 | |
| 13. Matt Ryan, QB | ATL | 30 | 40 | 275 | 3 | 1 | |
| 14. Matt Cassel, QB | KC | 26 | 44 | 248 | 0 | 1 | |
| 15. Cam Newton, QB | CAR | 16 | 30 | 242 | 0 | 3 | |
| 16. Drew Brees, QB | NO | 20 | 36 | 240 | 3 | 1 | |
| 17. Brandon Weeden, QB | CLE | 27 | 43 | 237 | 1 | 2 | |
| 18. Aaron Rodgers, QB | GB | 26 | 39 | 223 | 0 | 0 | |
| 19. Kevin Kolb, QB | ARI | 17 | 24 | 222 | 2 | 0 | |
| 20. Robert Griffin III, QB | WAS | 21 | 34 | 221 | 1 | 0 | |
| 21. Michael Vick, QB | PHI | 17 | 37 | 217 | 0 | 0 | |
| 22. Carson Palmer, QB | OAK | 24 | 34 | 209 | 3 | 1 | |
| 23. Ryan Fitzpatrick, QB | BUF | 22 | 35 | 208 | 3 | 0 | |
| 24. Alex Smith, QB | SF | 24 | 35 | 204 | 1 | 1 | |
| 25. Christian Ponder, QB | MIN | 21 | 35 | 198 | 2 | 0 | |
| 26. Ryan Tannehill, QB | MIA | 16 | 36 | 196 | 0 | 1 | |
| 27. Jay Cutler, QB | CHI | 17 | 31 | 183 | 0 | 1 | |
| 28. Philip Rivers, QB | SD | 21 | 38 | 173 | 0 | 2 | |
| 29. Shaun Hill, QB | DET | 10 | 13 | 172 | 2 | 0 | |
| 30. Blaine Gabbert, QB | JAC | 10 | 21 | 155 | 1 | 0 | |
| 31. Sam Bradford, QB | STL | 18 | 35 | 152 | 0 | 2 | |
| 32. Russell Wilson, QB | SEA | 10 | 21 | 130 | 2 | 0 | |
| 33. Josh Freeman, QB | TB | 10 | 28 | 110 | 1 | 1 | |
| 34. Mohamed Sanu, WR | CIN | 1 | 1 | 73 | 1 | 0 | |
| 35. Derek Anderson, QB | CAR | 3 | 3 | 46 | 0 | 0 | |
| 36. David Carr, QB | NYG | 1 | 2 | 4 | 0 | 0 | |
