| Passing | |||||||||||||||
| Player | Pos | Team | G | Att | Att/G | Cmp | Pct | Yds | Yds/G | Lng | TD | Int | Sck | SckYL | Rating |
| Matthew Stafford | QB | DET | 16 | 727 | 45.4 | 435 | 59.8 | 4967 | 310.4 | 57 | 20 | 17 | 29 | 212 | 79.8 |
| Drew Brees | QB | NO | 16 | 670 | 41.9 | 422 | 63.0 | 5177 | 323.6 | 80 | 43 | 19 | 26 | 190 | 96.3 |
| Tony Romo | QB | DAL | 16 | 648 | 40.5 | 425 | 65.6 | 4903 | 306.4 | 85 | 28 | 19 | 36 | 263 | 90.5 |
| Tom Brady | QB | NE | 16 | 637 | 39.8 | 401 | 63.0 | 4827 | 301.7 | 83 | 34 | 8 | 27 | 182 | 98.7 |
| Andrew Luck | QB | IND | 16 | 627 | 39.2 | 339 | 54.1 | 4374 | 273.4 | 70 | 23 | 18 | 41 | 246 | 76.5 |
| Matt Ryan | QB | ATL | 16 | 615 | 38.4 | 422 | 68.6 | 4719 | 294.9 | 80 | 32 | 14 | 28 | 210 | 99.1 |
| Peyton Manning | QB | DEN | 16 | 583 | 36.4 | 400 | 68.6 | 4659 | 291.2 | 71 | 37 | 11 | 21 | 137 | 105.8 |
| Carson Palmer | QB | OAK | 15 | 565 | 37.7 | 345 | 61.1 | 4018 | 267.9 | 64 | 22 | 14 | 26 | 199 | 85.3 |
| Josh Freeman | QB | TB | 16 | 558 | 34.9 | 306 | 54.8 | 4065 | 254.1 | 95 | 27 | 17 | 26 | 161 | 81.6 |
| Aaron Rodgers | QB | GB | 16 | 552 | 34.5 | 371 | 67.2 | 4295 | 268.4 | 73 | 39 | 8 | 51 | 293 | 108.0 |
| Sam Bradford | QB | STL | 16 | 551 | 34.4 | 328 | 59.5 | 3702 | 231.4 | 80 | 21 | 13 | 35 | 233 | 82.6 |
| Matt Schaub | QB | HOU | 16 | 544 | 34.0 | 350 | 64.3 | 4008 | 250.5 | 60 | 22 | 12 | 27 | 216 | 90.7 |
| Eli Manning | QB | NYG | 16 | 536 | 33.5 | 321 | 59.9 | 3948 | 246.8 | 80 | 26 | 15 | 19 | 136 | 87.2 |
| Joe Flacco | QB | BAL | 16 | 531 | 33.2 | 317 | 59.7 | 3817 | 238.6 | 61 | 22 | 10 | 35 | 227 | 87.7 |
| Andy Dalton | QB | CIN | 16 | 528 | 33.0 | 329 | 62.3 | 3669 | 229.3 | 59 | 27 | 16 | 46 | 229 | 87.4 |
| Philip Rivers | QB | SD | 16 | 527 | 32.9 | 338 | 64.1 | 3606 | 225.4 | 80 | 26 | 15 | 49 | 311 | 88.6 |
| Brandon Weeden | QB | CLE | 15 | 517 | 34.5 | 297 | 57.4 | 3385 | 225.7 | 71 | 14 | 17 | 28 | 186 | 72.6 |
| Ryan Fitzpatrick | QB | BUF | 16 | 505 | 31.6 | 306 | 60.6 | 3400 | 212.5 | 68 | 24 | 16 | 30 | 161 | 83.3 |
| Cam Newton | QB | CAR | 16 | 485 | 30.3 | 280 | 57.7 | 3869 | 241.8 | 82 | 19 | 12 | 36 | 244 | 86.2 |
| Ryan Tannehill | QB | MIA | 16 | 484 | 30.2 | 282 | 58.3 | 3294 | 205.9 | 80 | 12 | 13 | 35 | 234 | 76.1 |
| Christian Ponder | QB | MIN | 16 | 483 | 30.2 | 300 | 62.1 | 2935 | 183.4 | 65 | 18 | 12 | 32 | 184 | 81.2 |
| Mark Sanchez | QB | NYJ | 15 | 453 | 30.2 | 246 | 54.3 | 2883 | 192.2 | 66 | 13 | 18 | 34 | 209 | 66.9 |
| Ben Roethlisberger | QB | PIT | 13 | 449 | 34.5 | 284 | 63.3 | 3265 | 251.2 | 82 | 26 | 8 | 30 | 182 | 97.0 |
| Jay Cutler | QB | CHI | 15 | 434 | 28.9 | 255 | 58.8 | 3033 | 202.2 | 60 | 19 | 14 | 38 | 250 | 81.3 |
| Russell Wilson | QB | SEA | 16 | 393 | 24.6 | 252 | 64.1 | 3118 | 194.9 | 67 | 26 | 10 | 33 | 203 | 100.0 |
| Robert Griffin III | QB | WAS | 15 | 393 | 26.2 | 258 | 65.6 | 3200 | 213.3 | 88 | 20 | 5 | 30 | 217 | 102.4 |
| Michael Vick | QB | PHI | 10 | 351 | 35.1 | 204 | 58.1 | 2362 | 236.2 | 77 | 12 | 10 | 28 | 153 | 78.1 |
| Jake Locker | QB | TEN | 11 | 314 | 28.5 | 177 | 56.4 | 2176 | 197.8 | 71 | 10 | 11 | 25 | 151 | 74.0 |
| Chad Henne | QB | JAC | 10 | 308 | 30.8 | 166 | 53.9 | 2084 | 208.4 | 81 | 11 | 11 | 28 | 169 | 72.2 |
| Blaine Gabbert | QB | JAC | 10 | 278 | 27.8 | 162 | 58.3 | 1662 | 166.2 | 80 | 9 | 6 | 22 | 158 | 77.4 |
| Matt Cassel | QB | KC | 9 | 277 | 30.8 | 161 | 58.1 | 1796 | 199.6 | 46 | 6 | 12 | 19 | 101 | 66.7 |
| Nick Foles | QB | PHI | 7 | 265 | 37.9 | 161 | 60.8 | 1699 | 242.7 | 46 | 6 | 5 | 20 | 131 | 79.1 |
| Matt Hasselbeck | QB | TEN | 8 | 221 | 27.6 | 138 | 62.4 | 1367 | 170.9 | 37 | 7 | 5 | 14 | 103 | 81.0 |
| Colin Kaepernick | QB | SF | 13 | 218 | 16.8 | 136 | 62.4 | 1814 | 139.5 | 57 | 10 | 3 | 16 | 112 | 98.3 |
| Alex Smith | QB | SF | 10 | 218 | 21.8 | 153 | 70.2 | 1737 | 173.7 | 55 | 13 | 5 | 24 | 137 | 104.1 |
| John Skelton | QB | ARI | 7 | 201 | 28.7 | 109 | 54.2 | 1132 | 161.7 | 40 | 2 | 9 | 15 | 98 | 55.4 |
| Brady Quinn | QB | KC | 10 | 197 | 19.7 | 112 | 56.9 | 1141 | 114.1 | 57 | 2 | 8 | 21 | 123 | 60.1 |
| Kevin Kolb | QB | ARI | 6 | 183 | 30.5 | 109 | 59.6 | 1169 | 194.8 | 46 | 8 | 3 | 27 | 159 | 86.1 |
| Ryan Lindley | QB | ARI | 6 | 171 | 28.5 | 89 | 52.0 | 752 | 125.3 | 28 | 0 | 7 | 12 | 91 | 46.7 |
| Charlie Batch | QB | PIT | 2 | 70 | 35.0 | 45 | 64.3 | 475 | 237.5 | 43 | 1 | 4 | 3 | 12 | 64.9 |
| Brian Hoyer | QB | ARI | 2 | 53 | 26.5 | 30 | 56.6 | 330 | 165.0 | 53 | 1 | 2 | 4 | 30 | 65.8 |
| Byron Leftwich | QB | PIT | 2 | 53 | 26.5 | 25 | 47.2 | 272 | 136.0 | 37 | 0 | 1 | 3 | 24 | 54.9 |
| Jason Campbell | QB | CHI | 6 | 51 | 8.5 | 32 | 62.7 | 265 | 44.2 | 45 | 2 | 2 | 6 | 49 | 72.8 |
| Kirk Cousins | QB | WAS | 3 | 48 | 16.0 | 33 | 68.8 | 466 | 155.3 | 77 | 4 | 3 | 3 | 27 | 101.6 |
| Matt Leinart | QB | OAK | 2 | 33 | 16.5 | 16 | 48.5 | 115 | 57.5 | 20 | 0 | 1 | 1 | 9 | 44.4 |
| Thaddeus Lewis | QB | CLE | 1 | 32 | 32.0 | 22 | 68.8 | 204 | 204.0 | 23 | 1 | 1 | 3 | 14 | 83.3 |
| Greg McElroy | QB | NYJ | 2 | 31 | 15.5 | 19 | 61.3 | 214 | 107.0 | 30 | 1 | 1 | 11 | 71 | 79.2 |
| Terrelle Pryor | QB | OAK | 3 | 30 | 10.0 | 14 | 46.7 | 155 | 51.7 | 38 | 2 | 1 | 0 | 0 | 70.8 |
| Tyrod Taylor | QB | BAL | 7 | 29 | 4.1 | 17 | 58.6 | 179 | 25.6 | 25 | 0 | 1 | 3 | 30 | 62.3 |
| Matt Moore | QB | MIA | 2 | 19 | 9.5 | 11 | 57.9 | 131 | 65.5 | 37 | 1 | 0 | 2 | 9 | 96.6 |
| Colt McCoy | QB | CLE | 3 | 17 | 5.7 | 9 | 52.9 | 79 | 26.3 | 21 | 1 | 0 | 4 | 25 | 85.2 |
