| Sacks | ||||||||||||||||
| Interceptions | Fumbles | Tackles | Other | |||||||||||||
| Player | Pos | Team | G | Int | Yds | LG | TD | FF | Rec | TD | Cmb | Solo | Ast | Sack | Pdef | Sfty |
| Rob Ninkovich | DE | NE | 16 | 0 | 0 | 0 | 0 | 5 | 4 | 0 | 58 | 32 | 26 | 8.0 | 1 | 0 |
| Vince Wilfork | DT | NE | 16 | 0 | 0 | 0 | 0 | 2 | 4 | 0 | 48 | 29 | 19 | 3.0 | 6 | 0 |
| Julius Peppers | DE | CHI | 16 | 0 | 0 | 0 | 0 | 1 | 4 | 0 | 39 | 32 | 7 | 11.5 | 2 | 0 |
| Carlos Dunlap | DE | CIN | 14 | 1 | 14 | 14 | 1 | 4 | 3 | 0 | 40 | 33 | 7 | 6.0 | 4 | 0 |
| Shaun Phillips | OLB | SD | 16 | 0 | 0 | 0 | 0 | 2 | 3 | 1 | 50 | 33 | 17 | 9.5 | 3 | 1 |
| Wallace Gilberry | DE | CIN | 14 | 0 | 0 | 0 | 0 | 1 | 3 | 1 | 24 | 15 | 9 | 6.5 | 0 | 0 |
| C.J. Mosley | DT | JAC | 16 | 0 | 0 | 0 | 0 | 1 | 3 | 0 | 45 | 36 | 9 | 2.5 | 0 | 0 |
| Yeremiah Bell | SS | NYJ | 16 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 89 | 72 | 17 | 1.0 | 2 | 0 |
| Carlos Rogers | CB | SF | 16 | 1 | 63 | 63 | 0 | 0 | 3 | 1 | 56 | 50 | 6 | 1.0 | 8 | 0 |
| Luke Kuechly | MLB | CAR | 16 | 2 | 22 | 25 | 0 | 0 | 3 | 0 | 164 | 103 | 61 | 1.0 | 10 | 0 |
| J.J. Watt | DE | HOU | 16 | 0 | 0 | 0 | 0 | 4 | 2 | 0 | 81 | 69 | 12 | 20.5 | 16 | 0 |
| Cameron Jordan | DE | NO | 16 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 66 | 40 | 26 | 8.0 | 3 | 0 |
| Josh Wilson | CB | WAS | 16 | 2 | 8 | 7 | 0 | 3 | 2 | 1 | 74 | 54 | 20 | 1.0 | 15 | 0 |
| Mario Williams | DE | BUF | 16 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 46 | 37 | 9 | 10.5 | 4 | 0 |
| Larry Foote | ILB | PIT | 16 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 113 | 75 | 38 | 4.0 | 2 | 0 |
| D'Qwell Jackson | MLB | CLE | 16 | 2 | 31 | 27 | 1 | 2 | 2 | 0 | 118 | 63 | 55 | 3.5 | 9 | 0 |
| Curtis Lofton | MLB | NO | 16 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 123 | 82 | 41 | 1.0 | 7 | 0 |
| Mike Adams | SS | DEN | 16 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 80 | 60 | 20 | 1.0 | 11 | 1 |
| Reshad Jones | FS | MIA | 16 | 4 | 28 | 15 | 0 | 2 | 2 | 0 | 95 | 74 | 21 | 1.0 | 13 | 0 |
| Everson Griffen | DE | MIN | 16 | 1 | 29 | 29 | 1 | 1 | 2 | 0 | 26 | 23 | 3 | 8.0 | 3 | 0 |
| Zach Brown | OLB | TEN | 16 | 3 | 156 | 79 | 2 | 1 | 2 | 0 | 93 | 68 | 25 | 5.5 | 8 | 0 |
| Linval Joseph | DT | NYG | 16 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 59 | 33 | 26 | 4.0 | 0 | 0 |
| Antwan Barnes | LB | SD | 11 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 9 | 7 | 2 | 3.0 | 0 | 0 |
| Courtney Upshaw | OLB | BAL | 16 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 60 | 38 | 22 | 1.5 | 2 | 0 |
| Albert McClellan | OLB | BAL | 14 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 49 | 36 | 13 | 1.0 | 2 | 0 |
| Sheldon Brown | CB | CLE | 15 | 3 | 20 | 19 | 1 | 1 | 2 | 0 | 60 | 53 | 7 | 1.0 | 15 | 0 |
| Stephen Tulloch | MLB | DET | 16 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 112 | 74 | 38 | 0.5 | 6 | 0 |
| Dont'a Hightower | OLB | NE | 14 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 60 | 43 | 17 | 4.0 | 3 | 0 |
| Ziggy Hood | DE | PIT | 16 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 42 | 25 | 17 | 3.0 | 3 | 0 |
| Chad Greenway | OLB | MIN | 16 | 1 | 3 | 3 | 0 | 0 | 2 | 0 | 148 | 98 | 50 | 3.0 | 5 | 0 |
| Jermaine Cunningham | DE | NE | 12 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 24 | 16 | 8 | 2.5 | 0 | 0 |
| Frank Alexander | DE | CAR | 16 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 18 | 10 | 8 | 2.5 | 3 | 0 |
| Kevin Williams | DT | MIN | 16 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 30 | 19 | 11 | 2.0 | 7 | 0 |
| Mike Daniels | DE | GB | 14 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 12 | 12 | 0 | 2.0 | 1 | 0 |
| Vontaze Burfict | OLB | CIN | 16 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 127 | 73 | 54 | 1.0 | 2 | 0 |
| Billy Winn | DT | CLE | 16 | 1 | 0 | 0 | 0 | 0 | 2 | 0 | 26 | 19 | 7 | 1.0 | 4 | 0 |
| Craig Robertson | LB | CLE | 16 | 2 | 1 | 1 | 0 | 0 | 2 | 0 | 93 | 62 | 31 | 1.0 | 5 | 0 |
| Bradie James | ILB | HOU | 15 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 77 | 46 | 31 | 0.5 | 2 | 0 |
| Michael Boley | OLB | NYG | 16 | 3 | 74 | 51 | 0 | 0 | 2 | 1 | 92 | 65 | 27 | 0.5 | 7 | 0 |
| Charles Johnson | DE | CAR | 16 | 0 | 0 | 0 | 0 | 7 | 1 | 0 | 41 | 30 | 11 | 12.5 | 4 | 0 |
| DeMarcus Ware | OLB | DAL | 16 | 0 | 0 | 0 | 0 | 5 | 1 | 0 | 56 | 33 | 23 | 11.5 | 0 | 0 |
| Jerod Mayo | OLB | NE | 16 | 1 | 0 | 0 | 0 | 4 | 1 | 0 | 147 | 88 | 59 | 3.0 | 4 | 0 |
| Chris Clemons | DE | SEA | 16 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 40 | 31 | 9 | 11.5 | 4 | 0 |
| Brian Robison | DE | MIN | 15 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 37 | 26 | 11 | 8.5 | 7 | 0 |
| Muhammad Wilkerson | DE | NYJ | 16 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 70 | 38 | 32 | 5.0 | 4 | 0 |
| Danieal Manning | FS | HOU | 16 | 2 | 59 | 55 | 1 | 3 | 1 | 0 | 77 | 59 | 18 | 1.0 | 10 | 0 |
| William Gay | CB | ARI | 16 | 2 | 7 | 6 | 0 | 3 | 1 | 0 | 57 | 45 | 12 | 1.0 | 8 | 0 |
| Richard Sherman | CB | SEA | 16 | 8 | 57 | 29 | 1 | 3 | 1 | 0 | 64 | 53 | 11 | 1.0 | 32 | 0 |
| Anthony Spencer | OLB | DAL | 14 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 95 | 55 | 40 | 11.0 | 3 | 0 |
| Greg Hardy | DE | CAR | 15 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 61 | 41 | 20 | 11.0 | 2 | 0 |
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