| Sacks | ||||||||||||||||
| Interceptions | Fumbles | Tackles | Other | |||||||||||||
| Player | Pos | Team | G | Int | Yds | LG | TD | FF | Rec | TD | Cmb | Solo | Ast | Sack | Pdef | Sfty |
| Jordan Pugh | DB | WAS | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 19 | 17 | 2 | 1.0 | 1 | 0 |
| Brandon Deaderick | DT | NE | 14 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 18 | 10 | 8 | 1.0 | 1 | 0 |
| Lawrence Guy | DT | IND | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 18 | 12 | 6 | 1.0 | 0 | 0 |
| Shawne Merriman | LB | BUF | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 17 | 12 | 5 | 1.0 | 1 | 0 |
| Barrett Ruud | ILB | HOU | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 16 | 12 | 4 | 1.0 | 2 | 0 |
| Antonio Garay | DE | SD | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 16 | 7 | 9 | 1.0 | 0 | 0 |
| Drake Nevis | DE | IND | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 16 | 7 | 9 | 1.0 | 0 | 0 |
| Christian Ballard | DE | MIN | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 16 | 10 | 6 | 1.0 | 0 | 0 |
| George Selvie | DE | JAC | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 15 | 10 | 5 | 1.0 | 0 | 0 |
| Scott Fujita | OLB | CLE | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 14 | 10 | 4 | 1.0 | 0 | 0 |
| Ron Edwards | DT | CAR | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 14 | 7 | 7 | 1.0 | 0 | 0 |
| Frank Kearse | DT | CAR | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 13 | 8 | 5 | 1.0 | 0 | 0 |
| Amobi Okoye | DT | CHI | 9 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 12 | 9 | 3 | 1.0 | 0 | 0 |
| Mark Anderson | DE | BUF | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 12 | 10 | 2 | 1.0 | 1 | 0 |
| Adrian Tracy | LB | NYG | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 12 | 9 | 3 | 1.0 | 0 | 0 |
| Mario Haggan | OLB | STL | 11 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 12 | 10 | 2 | 1.0 | 0 | 0 |
| Bryan McCann | DB | MIA | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 10 | 10 | 0 | 1.0 | 1 | 0 |
| Emmanuel Stephens | DE | CLE | 8 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 9 | 8 | 1 | 1.0 | 0 | 0 |
| Nick Eason | DE | ARI | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 9 | 6 | 3 | 1.0 | 0 | 0 |
| Ronald Talley | DE | ARI | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 5 | 3 | 1.0 | 1 | 0 |
| Phillip Hunt | DE | PHI | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 8 | 0 | 1.0 | 0 | 0 |
| Antwan Applewhite | DE | CAR | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 1 | 5 | 1.0 | 0 | 0 |
| Mike Patterson | DT | PHI | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 3 | 3 | 1.0 | 0 | 0 |
| Derrick Martin | DB | NE | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 4 | 1 | 1.0 | 0 | 0 |
| Clifton Geathers | DE | IND | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 3 | 2 | 1.0 | 0 | 0 |
| Brian Orakpo | OLB | WAS | 2 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 5 | 5 | 0 | 1.0 | 3 | 0 |
| Mario Addison | OLB | CAR | 4 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 5 | 5 | 0 | 1.0 | 0 | 0 |
| Tim Jamison | DE | HOU | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 1 | 1.0 | 1 | 0 |
| Jamaal Westerman | LB | IND | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3 | 0 | 1.0 | 0 | 0 |
| Thomas Howard | LB | CIN | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3 | 0 | 1.0 | 1 | 0 |
| Omar Brown | DB | BAL | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 1 | 1.0 | 0 | 0 |
| DeMeco Ryans | MLB | PHI | 16 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 113 | 86 | 27 | 1.0 | 5 | 0 |
| Madieu Williams | FS | WAS | 16 | 1 | 24 | 24 | 1 | 0 | 0 | 0 | 99 | 66 | 33 | 1.0 | 7 | 0 |
| K.J. Wright | OLB | SEA | 15 | 1 | 24 | 24 | 0 | 1 | 0 | 0 | 98 | 68 | 30 | 1.0 | 6 | 0 |
| T.J. Ward | SS | CLE | 14 | 1 | 37 | 37 | 0 | 3 | 0 | 0 | 68 | 50 | 18 | 1.0 | 5 | 0 |
| Mike Harris | CB | JAC | 15 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 55 | 51 | 4 | 1.0 | 7 | 0 |
| E.J. Biggers | CB | TB | 13 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 51 | 41 | 10 | 1.0 | 8 | 0 |
| Will Witherspoon | MLB | TEN | 14 | 1 | 40 | 40 | 1 | 1 | 0 | 0 | 47 | 29 | 18 | 1.0 | 3 | 0 |
| Rocky McIntosh | OLB | STL | 16 | 1 | 34 | 34 | 0 | 0 | 0 | 0 | 45 | 34 | 11 | 1.0 | 2 | 0 |
| Tom Zbikowski | SS | IND | 11 | 1 | 20 | 20 | 0 | 0 | 0 | 0 | 38 | 27 | 11 | 1.0 | 6 | 0 |
| Jonathan Vilma | OLB | NO | 11 | 1 | 18 | 18 | 1 | 0 | 0 | 0 | 37 | 20 | 17 | 1.0 | 3 | 0 |
| Troy Polamalu | SS | PIT | 7 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 34 | 29 | 5 | 1.0 | 4 | 0 |
| Jonte Green | CB | DET | 15 | 1 | 18 | 18 | 0 | 0 | 0 | 0 | 29 | 23 | 6 | 1.0 | 5 | 0 |
| Bradley Fletcher | CB | STL | 16 | 1 | 2 | 2 | 0 | 1 | 0 | 0 | 28 | 23 | 5 | 1.0 | 9 | 0 |
| L.J. Fort | OLB | CLE | 16 | 1 | 10 | 10 | 0 | 0 | 0 | 0 | 20 | 13 | 7 | 1.0 | 4 | 0 |
| Glover Quin | SS | HOU | 16 | 2 | 22 | 22 | 0 | 2 | 0 | 0 | 84 | 64 | 20 | 1.0 | 16 | 0 |
| Ellis Lankster | DB | NYJ | 15 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 39 | 33 | 6 | 1.0 | 8 | 0 |
| Cortland Finnegan | CB | STL | 16 | 3 | 68 | 32 | 1 | 1 | 0 | 0 | 101 | 83 | 18 | 1.0 | 11 | 0 |
| Eric Weddle | FS | SD | 16 | 3 | 52 | 23 | 1 | 2 | 0 | 0 | 97 | 83 | 14 | 1.0 | 12 | 0 |
| Reggie Nelson | FS | CIN | 14 | 3 | 10 | 10 | 0 | 2 | 0 | 0 | 85 | 56 | 29 | 1.0 | 12 | 0 |
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