| Sacks | ||||||||||||||||
| Interceptions | Fumbles | Tackles | Other | |||||||||||||
| Player | Pos | Team | G | Int | Yds | LG | TD | FF | Rec | TD | Cmb | Solo | Ast | Sack | Pdef | Sfty |
| Muhammad Wilkerson | DE | NYJ | 16 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 70 | 38 | 32 | 5.0 | 4 | 0 |
| Michael Boley | OLB | NYG | 16 | 3 | 74 | 51 | 0 | 0 | 2 | 1 | 92 | 65 | 27 | 0.5 | 7 | 0 |
| Jason Hatcher | DE | DAL | 16 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 51 | 27 | 24 | 4.0 | 1 | 0 |
| Josh Wilson | CB | WAS | 16 | 2 | 8 | 7 | 0 | 3 | 2 | 1 | 74 | 54 | 20 | 1.0 | 15 | 0 |
| Shaun Phillips | OLB | SD | 16 | 0 | 0 | 0 | 0 | 2 | 3 | 1 | 50 | 33 | 17 | 9.5 | 3 | 1 |
| Dont'a Hightower | OLB | NE | 14 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 60 | 43 | 17 | 4.0 | 3 | 0 |
| Wallace Gilberry | DE | CIN | 14 | 0 | 0 | 0 | 0 | 1 | 3 | 1 | 24 | 15 | 9 | 6.5 | 0 | 0 |
| Jonathan Babineaux | DT | ATL | 16 | 1 | -2 | -2 | 0 | 1 | 1 | 1 | 31 | 25 | 6 | 3.5 | 6 | 0 |
| Carlos Rogers | CB | SF | 16 | 1 | 63 | 63 | 0 | 0 | 3 | 1 | 56 | 50 | 6 | 1.0 | 8 | 0 |
| Mike Daniels | DE | GB | 14 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 12 | 12 | 0 | 2.0 | 1 | 0 |
| London Fletcher | ILB | WAS | 16 | 5 | 29 | 10 | 0 | 1 | 0 | 0 | 139 | 78 | 61 | 3.0 | 16 | 0 |
| Luke Kuechly | MLB | CAR | 16 | 2 | 22 | 25 | 0 | 0 | 3 | 0 | 164 | 103 | 61 | 1.0 | 10 | 0 |
| Rey Maualuga | MLB | CIN | 16 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 122 | 62 | 60 | 1.0 | 4 | 0 |
| Jerod Mayo | OLB | NE | 16 | 1 | 0 | 0 | 0 | 4 | 1 | 0 | 147 | 88 | 59 | 3.0 | 4 | 0 |
| Perry Riley | ILB | WAS | 16 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 129 | 73 | 56 | 3.5 | 7 | 0 |
| D'Qwell Jackson | MLB | CLE | 16 | 2 | 31 | 27 | 1 | 2 | 2 | 0 | 118 | 63 | 55 | 3.5 | 9 | 0 |
| Jerrell Freeman | ILB | IND | 16 | 1 | 4 | 4 | 1 | 1 | 0 | 0 | 145 | 90 | 55 | 2.0 | 3 | 0 |
| Bobby Wagner | MLB | SEA | 16 | 3 | 55 | 45 | 0 | 0 | 0 | 0 | 140 | 86 | 54 | 2.0 | 7 | 0 |
| Vontaze Burfict | OLB | CIN | 16 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 127 | 73 | 54 | 1.0 | 2 | 0 |
| NaVorro Bowman | ILB | SF | 16 | 1 | 11 | 11 | 0 | 1 | 0 | 0 | 149 | 97 | 52 | 2.0 | 7 | 0 |
| Chad Greenway | OLB | MIN | 16 | 1 | 3 | 3 | 0 | 0 | 2 | 0 | 148 | 98 | 50 | 3.0 | 5 | 0 |
| Wesley Woodyard | OLB | DEN | 15 | 3 | 40 | 25 | 0 | 1 | 1 | 0 | 117 | 73 | 44 | 5.5 | 9 | 0 |
| David Harris | ILB | NYJ | 16 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 123 | 80 | 43 | 3.0 | 3 | 0 |
| Curtis Lofton | MLB | NO | 16 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 123 | 82 | 41 | 1.0 | 7 | 0 |
| Anthony Spencer | OLB | DAL | 14 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 95 | 55 | 40 | 11.0 | 3 | 0 |
| Nick Barnett | OLB | BUF | 16 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 112 | 72 | 40 | 2.0 | 1 | 0 |
| A.J. Hawk | ILB | GB | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 120 | 81 | 39 | 3.0 | 0 | 0 |
| Larry Foote | ILB | PIT | 16 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 113 | 75 | 38 | 4.0 | 2 | 0 |
| Stephen Tulloch | MLB | DET | 16 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 112 | 74 | 38 | 0.5 | 6 | 0 |
| Akeem Ayers | OLB | TEN | 16 | 1 | 2 | 2 | 0 | 1 | 0 | 0 | 103 | 66 | 37 | 6.0 | 9 | 0 |
| Morgan Burnett | SS | GB | 16 | 2 | 1 | 1 | 0 | 2 | 1 | 0 | 123 | 88 | 35 | 2.0 | 7 | 0 |
| Brandon Spikes | MLB | NE | 15 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 92 | 57 | 35 | 1.0 | 7 | 0 |
| Chase Blackburn | MLB | NYG | 15 | 1 | 0 | 0 | 0 | 4 | 0 | 0 | 98 | 64 | 34 | 3.0 | 7 | 0 |
| Miles Burris | OLB | OAK | 16 | 1 | 7 | 7 | 0 | 0 | 0 | 0 | 96 | 62 | 34 | 1.5 | 4 | 0 |
| Paul Posluszny | MLB | JAC | 16 | 3 | 20 | 13 | 0 | 2 | 0 | 0 | 139 | 106 | 33 | 2.0 | 10 | 0 |
| Karlos Dansby | MLB | MIA | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 133 | 100 | 33 | 1.0 | 9 | 0 |
| Madieu Williams | FS | WAS | 16 | 1 | 24 | 24 | 1 | 0 | 0 | 0 | 99 | 66 | 33 | 1.0 | 7 | 0 |
| Patrick Willis | ILB | SF | 16 | 2 | 2 | 2 | 0 | 2 | 1 | 0 | 120 | 88 | 32 | 0.5 | 11 | 0 |
| Lawrence Timmons | ILB | PIT | 16 | 3 | 80 | 53 | 1 | 2 | 1 | 0 | 106 | 75 | 31 | 6.0 | 8 | 0 |
| Philip Wheeler | OLB | OAK | 16 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 109 | 78 | 31 | 3.0 | 6 | 0 |
| Craig Robertson | LB | CLE | 16 | 2 | 1 | 1 | 0 | 0 | 2 | 0 | 93 | 62 | 31 | 1.0 | 5 | 0 |
| Bradie James | ILB | HOU | 15 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 77 | 46 | 31 | 0.5 | 2 | 0 |
| Domata Peko | DT | CIN | 16 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 53 | 23 | 30 | 2.0 | 3 | 0 |
| K.J. Wright | OLB | SEA | 15 | 1 | 24 | 24 | 0 | 1 | 0 | 0 | 98 | 68 | 30 | 1.0 | 6 | 0 |
| Harrison Smith | FS | MIN | 16 | 3 | 87 | 56 | 2 | 1 | 1 | 0 | 103 | 73 | 30 | 1.0 | 14 | 0 |
| Erin Henderson | OLB | MIN | 14 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 79 | 50 | 29 | 3.0 | 2 | 0 |
| Kevin Burnett | OLB | MIA | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 110 | 81 | 29 | 2.5 | 5 | 0 |
| Paris Lenon | ILB | ARI | 16 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 102 | 73 | 29 | 2.0 | 4 | 0 |
| Lance Briggs | OLB | CHI | 16 | 2 | 110 | 74 | 2 | 2 | 0 | 0 | 102 | 73 | 29 | 1.5 | 13 | 0 |
| Reggie Nelson | FS | CIN | 14 | 3 | 10 | 10 | 0 | 2 | 0 | 0 | 85 | 56 | 29 | 1.0 | 12 | 0 |
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