| Sacks | ||||||||||||||||
| Interceptions | Fumbles | Tackles | Other | |||||||||||||
| Player | Pos | Team | G | Int | Yds | LG | TD | FF | Rec | TD | Cmb | Solo | Ast | Sack | Pdef | Sfty |
| Chris Cook | CB | MIN | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 35 | 27 | 8 | 1.0 | 5 | 0 |
| Davon House | CB | GB | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 26 | 20 | 6 | 1.0 | 5 | 0 |
| DeMeco Ryans | MLB | PHI | 16 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 113 | 86 | 27 | 1.0 | 5 | 0 |
| T.J. Ward | SS | CLE | 14 | 1 | 37 | 37 | 0 | 3 | 0 | 0 | 68 | 50 | 18 | 1.0 | 5 | 0 |
| Jonte Green | CB | DET | 15 | 1 | 18 | 18 | 0 | 0 | 0 | 0 | 29 | 23 | 6 | 1.0 | 5 | 0 |
| Craig Robertson | LB | CLE | 16 | 2 | 1 | 1 | 0 | 0 | 2 | 0 | 93 | 62 | 31 | 1.0 | 5 | 0 |
| Charles Johnson | DE | CAR | 16 | 0 | 0 | 0 | 0 | 7 | 1 | 0 | 41 | 30 | 11 | 12.5 | 4 | 0 |
| Chris Clemons | DE | SEA | 16 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 40 | 31 | 9 | 11.5 | 4 | 0 |
| Mario Williams | DE | BUF | 16 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 46 | 37 | 9 | 10.5 | 4 | 0 |
| Carlos Dunlap | DE | CIN | 14 | 1 | 14 | 14 | 1 | 4 | 3 | 0 | 40 | 33 | 7 | 6.0 | 4 | 0 |
| Fletcher Cox | DT | PHI | 15 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 39 | 32 | 7 | 5.5 | 4 | 0 |
| Muhammad Wilkerson | DE | NYJ | 16 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 70 | 38 | 32 | 5.0 | 4 | 0 |
| Jason Jones | DE | SEA | 12 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 10 | 7 | 3 | 3.0 | 4 | 0 |
| Jerod Mayo | OLB | NE | 16 | 1 | 0 | 0 | 0 | 4 | 1 | 0 | 147 | 88 | 59 | 3.0 | 4 | 0 |
| Derrick Johnson | ILB | KC | 16 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 125 | 110 | 15 | 2.0 | 4 | 0 |
| Brad Jones | ILB | GB | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 77 | 56 | 21 | 2.0 | 4 | 0 |
| Jimmy Wilson | CB | MIA | 15 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 40 | 34 | 6 | 2.0 | 4 | 0 |
| D.J. Smith | ILB | GB | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 39 | 29 | 10 | 2.0 | 4 | 0 |
| Cory Redding | DE | IND | 14 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 36 | 22 | 14 | 2.0 | 4 | 0 |
| Terrell Suggs | OLB | BAL | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 22 | 17 | 5 | 2.0 | 4 | 0 |
| Paris Lenon | ILB | ARI | 16 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 102 | 73 | 29 | 2.0 | 4 | 0 |
| Nick Roach | OLB | CHI | 16 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 66 | 51 | 15 | 1.5 | 4 | 0 |
| Darnell Dockett | DE | ARI | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 34 | 23 | 11 | 1.5 | 4 | 0 |
| Miles Burris | OLB | OAK | 16 | 1 | 7 | 7 | 0 | 0 | 0 | 0 | 96 | 62 | 34 | 1.5 | 4 | 0 |
| Rey Maualuga | MLB | CIN | 16 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 122 | 62 | 60 | 1.0 | 4 | 0 |
| Kavell Conner | ILB | IND | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 54 | 37 | 17 | 1.0 | 4 | 0 |
| Troy Polamalu | SS | PIT | 7 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 34 | 29 | 5 | 1.0 | 4 | 0 |
| Billy Winn | DT | CLE | 16 | 1 | 0 | 0 | 0 | 0 | 2 | 0 | 26 | 19 | 7 | 1.0 | 4 | 0 |
| L.J. Fort | OLB | CLE | 16 | 1 | 10 | 10 | 0 | 0 | 0 | 0 | 20 | 13 | 7 | 1.0 | 4 | 0 |
| Von Miller | OLB | DEN | 16 | 1 | 26 | 26 | 1 | 6 | 0 | 0 | 68 | 55 | 13 | 18.5 | 3 | 0 |
| Jared Allen | DE | MIN | 16 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 45 | 35 | 10 | 12.0 | 3 | 0 |
| Michael Johnson | DE | CIN | 16 | 1 | 3 | 3 | 0 | 0 | 1 | 0 | 52 | 35 | 17 | 11.5 | 3 | 0 |
| Anthony Spencer | OLB | DAL | 14 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 95 | 55 | 40 | 11.0 | 3 | 0 |
| Shaun Phillips | OLB | SD | 16 | 0 | 0 | 0 | 0 | 2 | 3 | 1 | 50 | 33 | 17 | 9.5 | 3 | 1 |
| Cameron Jordan | DE | NO | 16 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 66 | 40 | 26 | 8.0 | 3 | 0 |
| Robert Mathis | OLB | IND | 12 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 33 | 22 | 11 | 8.0 | 3 | 0 |
| Everson Griffen | DE | MIN | 16 | 1 | 29 | 29 | 1 | 1 | 2 | 0 | 26 | 23 | 3 | 8.0 | 3 | 0 |
| Jabaal Sheard | DE | CLE | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 54 | 37 | 17 | 7.0 | 3 | 0 |
| Antonio Smith | DE | HOU | 16 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 30 | 22 | 8 | 7.0 | 3 | 0 |
| Dont'a Hightower | OLB | NE | 14 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 60 | 43 | 17 | 4.0 | 3 | 0 |
| David Harris | ILB | NYJ | 16 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 123 | 80 | 43 | 3.0 | 3 | 0 |
| Brandon Mebane | DT | SEA | 16 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 56 | 31 | 25 | 3.0 | 3 | 0 |
| Tyson Jackson | DE | KC | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 43 | 31 | 12 | 3.0 | 3 | 0 |
| Ziggy Hood | DE | PIT | 16 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 42 | 25 | 17 | 3.0 | 3 | 0 |
| Victor Butler | OLB | DAL | 16 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 25 | 21 | 4 | 3.0 | 3 | 0 |
| Brooks Reed | OLB | HOU | 12 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 27 | 19 | 8 | 2.5 | 3 | 0 |
| Frank Alexander | DE | CAR | 16 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 18 | 10 | 8 | 2.5 | 3 | 0 |
| Kaluka Maiava | OLB | CLE | 16 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 53 | 35 | 18 | 2.0 | 3 | 0 |
| Domata Peko | DT | CIN | 16 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 53 | 23 | 30 | 2.0 | 3 | 0 |
| Alex Carrington | DE | BUF | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 19 | 12 | 7 | 2.0 | 3 | 0 |
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