| Sacks | ||||||||||||||||
| Interceptions | Fumbles | Tackles | Other | |||||||||||||
| Player | Pos | Team | G | Int | Yds | LG | TD | FF | Rec | TD | Cmb | Solo | Ast | Sack | Pdef | Sfty |
| Erik Walden | OLB | GB | 15 | 2 | 22 | 20 | 0 | 0 | 0 | 0 | 46 | 27 | 19 | 3.0 | 6 | 0 |
| London Fletcher | ILB | WAS | 16 | 5 | 29 | 10 | 0 | 1 | 0 | 0 | 139 | 78 | 61 | 3.0 | 16 | 0 |
| Kevin Burnett | OLB | MIA | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 110 | 81 | 29 | 2.5 | 5 | 0 |
| Lorenzo Alexander | LB | WAS | 16 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 47 | 34 | 13 | 2.5 | 0 | 0 |
| C.J. Mosley | DT | JAC | 16 | 0 | 0 | 0 | 0 | 1 | 3 | 0 | 45 | 36 | 9 | 2.5 | 0 | 0 |
| Barry Cofield | NT | WAS | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 36 | 15 | 21 | 2.5 | 6 | 0 |
| Brooks Reed | OLB | HOU | 12 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 27 | 19 | 8 | 2.5 | 3 | 0 |
| C.J. Wilson | DE | GB | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 24 | 15 | 9 | 2.5 | 1 | 0 |
| Stephen Paea | DT | CHI | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 24 | 13 | 11 | 2.5 | 0 | 0 |
| Bryan Thomas | OLB | NYJ | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 24 | 18 | 6 | 2.5 | 1 | 0 |
| Jermaine Cunningham | DE | NE | 12 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 24 | 16 | 8 | 2.5 | 0 | 0 |
| Brodrick Bunkley | DT | NO | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 23 | 10 | 13 | 2.5 | 2 | 0 |
| Lawrence Jackson | DE | DET | 15 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 20 | 11 | 9 | 2.5 | 0 | 0 |
| Andre Carter | DE | OAK | 12 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 19 | 13 | 6 | 2.5 | 0 | 0 |
| Frank Alexander | DE | CAR | 16 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 18 | 10 | 8 | 2.5 | 3 | 0 |
| Jerel Worthy | DE | GB | 14 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 14 | 11 | 3 | 2.5 | 0 | 0 |
| Shea McClellin | DE | CHI | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 14 | 7 | 7 | 2.5 | 0 | 0 |
| Bart Scott | ILB | NYJ | 15 | 1 | 11 | 11 | 0 | 0 | 1 | 0 | 60 | 36 | 24 | 2.5 | 2 | 0 |
| Chris Harris | CB | DEN | 15 | 3 | 144 | 98 | 2 | 0 | 0 | 0 | 61 | 51 | 10 | 2.5 | 15 | 0 |
| Derrick Johnson | ILB | KC | 16 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 125 | 110 | 15 | 2.0 | 4 | 0 |
| Nick Barnett | OLB | BUF | 16 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 112 | 72 | 40 | 2.0 | 1 | 0 |
| Antoine Bethea | FS | IND | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 100 | 75 | 25 | 2.0 | 7 | 0 |
| Kelvin Sheppard | MLB | BUF | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 80 | 56 | 24 | 2.0 | 1 | 0 |
| Brad Jones | ILB | GB | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 77 | 56 | 21 | 2.0 | 4 | 0 |
| Kaluka Maiava | OLB | CLE | 16 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 53 | 35 | 18 | 2.0 | 3 | 0 |
| Domata Peko | DT | CIN | 16 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 53 | 23 | 30 | 2.0 | 3 | 0 |
| Ropati Pitoitua | DE | KC | 15 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 51 | 32 | 19 | 2.0 | 1 | 0 |
| Ahtyba Rubin | DT | CLE | 13 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 44 | 30 | 14 | 2.0 | 2 | 0 |
| Jimmy Wilson | CB | MIA | 15 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 40 | 34 | 6 | 2.0 | 4 | 0 |
| Kevin Vickerson | DT | DEN | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 40 | 28 | 12 | 2.0 | 1 | 0 |
| D.J. Smith | ILB | GB | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 39 | 29 | 10 | 2.0 | 4 | 0 |
| Manny Lawson | OLB | CIN | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 39 | 30 | 9 | 2.0 | 1 | 0 |
| Cory Redding | DE | IND | 14 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 36 | 22 | 14 | 2.0 | 4 | 0 |
| Austen Lane | DE | JAC | 11 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 32 | 22 | 10 | 2.0 | 0 | 0 |
| Terrance Knighton | DT | JAC | 16 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 32 | 20 | 12 | 2.0 | 1 | 0 |
| Letroy Guion | DT | MIN | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 31 | 16 | 15 | 2.0 | 1 | 0 |
| Kevin Williams | DT | MIN | 16 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 30 | 19 | 11 | 2.0 | 7 | 0 |
| Tom Johnson | DT | NO | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 29 | 19 | 10 | 2.0 | 0 | 0 |
| Kendall Langford | DT | STL | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 27 | 18 | 9 | 2.0 | 2 | 0 |
| Fred Evans | DT | MIN | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 23 | 15 | 8 | 2.0 | 2 | 0 |
| Terrell Suggs | OLB | BAL | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 22 | 17 | 5 | 2.0 | 4 | 0 |
| Ricky Jean Francois | NT | SF | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 22 | 12 | 10 | 2.0 | 0 | 0 |
| Spencer Johnson | DT | BUF | 14 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 19 | 10 | 9 | 2.0 | 2 | 0 |
| Alex Carrington | DE | BUF | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 19 | 12 | 7 | 2.0 | 3 | 0 |
| Nick Perry | OLB | GB | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 18 | 13 | 5 | 2.0 | 1 | 0 |
| Robert Ayers | DE | DEN | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 16 | 8 | 8 | 2.0 | 2 | 0 |
| Jeron Johnson | SS | SEA | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 12 | 7 | 5 | 2.0 | 0 | 0 |
| Mike Daniels | DE | GB | 14 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 12 | 12 | 0 | 2.0 | 1 | 0 |
| Corey Williams | DT | DET | 7 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 9 | 5 | 4 | 2.0 | 0 | 0 |
| Steve McLendon | DT | PIT | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 7 | 4 | 3 | 2.0 | 0 | 0 |
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