| Sacks | ||||||||||||||||
| Interceptions | Fumbles | Tackles | Other | |||||||||||||
| Player | Pos | Team | G | Int | Yds | LG | TD | FF | Rec | TD | Cmb | Solo | Ast | Sack | Pdef | Sfty |
| Jason Jones | DE | SEA | 12 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 10 | 7 | 3 | 3.0 | 4 | 0 |
| Eugene Sims | DE | STL | 13 | 1 | 5 | 5 | 0 | 0 | 0 | 0 | 20 | 15 | 5 | 3.0 | 2 | 0 |
| Ray McDonald | DE | SF | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 38 | 28 | 10 | 2.5 | 1 | 1 |
| C.J. Wilson | DE | GB | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 24 | 15 | 9 | 2.5 | 1 | 0 |
| Jermaine Cunningham | DE | NE | 12 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 24 | 16 | 8 | 2.5 | 0 | 0 |
| Lawrence Jackson | DE | DET | 15 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 20 | 11 | 9 | 2.5 | 0 | 0 |
| Andre Carter | DE | OAK | 12 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 19 | 13 | 6 | 2.5 | 0 | 0 |
| Frank Alexander | DE | CAR | 16 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 18 | 10 | 8 | 2.5 | 3 | 0 |
| Jerel Worthy | DE | GB | 14 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 14 | 11 | 3 | 2.5 | 0 | 0 |
| Shea McClellin | DE | CHI | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 14 | 7 | 7 | 2.5 | 0 | 0 |
| Ropati Pitoitua | DE | KC | 15 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 51 | 32 | 19 | 2.0 | 1 | 0 |
| Cory Redding | DE | IND | 14 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 36 | 22 | 14 | 2.0 | 4 | 0 |
| Austen Lane | DE | JAC | 11 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 32 | 22 | 10 | 2.0 | 0 | 0 |
| Alex Carrington | DE | BUF | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 19 | 12 | 7 | 2.0 | 3 | 0 |
| Robert Ayers | DE | DEN | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 16 | 8 | 8 | 2.0 | 2 | 0 |
| Chris Kelsay | DE | BUF | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 14 | 12 | 2 | 2.0 | 0 | 1 |
| Mike Daniels | DE | GB | 14 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 12 | 12 | 0 | 2.0 | 1 | 0 |
| Jarius Wynn | DE | TEN | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 6 | 0 | 2.0 | 1 | 0 |
| Greg Scruggs | DE | SEA | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 5 | 1 | 2.0 | 1 | 0 |
| Darnell Dockett | DE | ARI | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 34 | 23 | 11 | 1.5 | 4 | 0 |
| Pernell McPhee | DE | BAL | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 21 | 18 | 3 | 1.5 | 0 | 0 |
| Cameron Heyward | DE | PIT | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 20 | 13 | 7 | 1.5 | 0 | 0 |
| Jason Babin | DE | JAC | 5 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 11 | 7 | 4 | 1.5 | 0 | 0 |
| Mike DeVito | DE | NYJ | 16 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 52 | 27 | 25 | 1.0 | 0 | 0 |
| Marcus Spears | DE | DAL | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 25 | 7 | 18 | 1.0 | 1 | 0 |
| Stephen Bowen | DE | WAS | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 25 | 12 | 13 | 1.0 | 3 | 0 |
| Vaughn Martin | DE | SD | 12 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 19 | 12 | 7 | 1.0 | 0 | 0 |
| Antonio Garay | DE | SD | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 16 | 7 | 9 | 1.0 | 0 | 0 |
| Drake Nevis | DE | IND | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 16 | 7 | 9 | 1.0 | 0 | 0 |
| Christian Ballard | DE | MIN | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 16 | 10 | 6 | 1.0 | 0 | 0 |
| George Selvie | DE | JAC | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 15 | 10 | 5 | 1.0 | 0 | 0 |
| Mark Anderson | DE | BUF | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 12 | 10 | 2 | 1.0 | 1 | 0 |
| Andre Branch | DE | JAC | 13 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 12 | 9 | 3 | 1.0 | 1 | 0 |
| Emmanuel Stephens | DE | CLE | 8 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 9 | 8 | 1 | 1.0 | 0 | 0 |
| Nick Eason | DE | ARI | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 9 | 6 | 3 | 1.0 | 0 | 0 |
| Ronald Talley | DE | ARI | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 5 | 3 | 1.0 | 1 | 0 |
| Phillip Hunt | DE | PHI | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 8 | 0 | 1.0 | 0 | 0 |
| Antwan Applewhite | DE | CAR | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 1 | 5 | 1.0 | 0 | 0 |
| Clifton Geathers | DE | IND | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 3 | 2 | 1.0 | 0 | 0 |
| Tim Jamison | DE | HOU | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 1 | 1.0 | 1 | 0 |
| Darryl Tapp | DE | PHI | 13 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 17 | 13 | 4 | 0.5 | 0 | 0 |
| Dave Tollefson | DE | OAK | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 6 | 2 | 0.5 | 0 | 0 |
| Thomas Keiser | DE | CAR | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 2 | 2 | 0.5 | 0 | 0 |
| Geno Atkins | DT | CIN | 16 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 53 | 39 | 14 | 12.5 | 2 | 0 |
| Ndamukong Suh | DT | DET | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 35 | 25 | 10 | 8.0 | 2 | 0 |
| Dwan Edwards | DT | CAR | 14 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 52 | 27 | 25 | 6.0 | 1 | 0 |
| Henry Melton | DT | CHI | 14 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 43 | 31 | 12 | 6.0 | 0 | 0 |
| Fletcher Cox | DT | PHI | 15 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 39 | 32 | 7 | 5.5 | 4 | 0 |
| Marcell Dareus | DT | BUF | 16 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 39 | 26 | 13 | 5.5 | 6 | 0 |
| Nick Fairley | DT | DET | 13 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 34 | 27 | 7 | 5.5 | 1 | 0 |
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