| Sacks | ||||||||||||||||
| Interceptions | Fumbles | Tackles | Other | |||||||||||||
| Player | Pos | Team | G | Int | Yds | LG | TD | FF | Rec | TD | Cmb | Solo | Ast | Sack | Pdef | Sfty |
| Paris Lenon | ILB | ARI | 16 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 102 | 73 | 29 | 2.0 | 4 | 0 |
| Daryl Washington | ILB | ARI | 16 | 1 | 7 | 7 | 0 | 2 | 1 | 0 | 134 | 108 | 26 | 9.0 | 5 | 0 |
| Adrian Wilson | SS | ARI | 15 | 1 | -2 | -2 | 0 | 1 | 0 | 0 | 54 | 39 | 15 | 3.0 | 6 | 0 |
| Calais Campbell | DE | ARI | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 63 | 50 | 13 | 6.5 | 6 | 0 |
| Sam Acho | OLB | ARI | 16 | 2 | 2 | 2 | 0 | 2 | 0 | 0 | 48 | 35 | 13 | 4.0 | 5 | 0 |
| William Gay | CB | ARI | 16 | 2 | 7 | 6 | 0 | 3 | 1 | 0 | 57 | 45 | 12 | 1.0 | 8 | 0 |
| Darnell Dockett | DE | ARI | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 34 | 23 | 11 | 1.5 | 4 | 0 |
| Quentin Groves | OLB | ARI | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 46 | 37 | 9 | 4.0 | 0 | 0 |
| Kerry Rhodes | FS | ARI | 15 | 4 | 39 | 30 | 0 | 2 | 0 | 0 | 67 | 58 | 9 | 1.0 | 15 | 0 |
| O'Brien Schofield | OLB | ARI | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 34 | 26 | 8 | 4.0 | 0 | 0 |
| Nick Eason | DE | ARI | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 9 | 6 | 3 | 1.0 | 0 | 0 |
| Ronald Talley | DE | ARI | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 5 | 3 | 1.0 | 1 | 0 |
| Sean Weatherspoon | OLB | ATL | 13 | 1 | 6 | 6 | 0 | 1 | 1 | 0 | 95 | 70 | 25 | 3.0 | 5 | 0 |
| Stephen Nicholas | OLB | ATL | 16 | 1 | 3 | 3 | 0 | 1 | 1 | 0 | 97 | 72 | 25 | 2.0 | 5 | 0 |
| William Moore | SS | ATL | 12 | 4 | 51 | 33 | 0 | 2 | 1 | 0 | 75 | 59 | 16 | 1.0 | 12 | 0 |
| Kroy Biermann | DE | ATL | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 52 | 37 | 15 | 4.0 | 0 | 0 |
| Thomas DeCoud | FS | ATL | 16 | 6 | 42 | 24 | 0 | 0 | 1 | 0 | 76 | 62 | 14 | 1.0 | 15 | 0 |
| Dunta Robinson | CB | ATL | 16 | 1 | 4 | 4 | 0 | 1 | 0 | 0 | 80 | 67 | 13 | 1.5 | 9 | 0 |
| Vance Walker | DE | ATL | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 32 | 21 | 11 | 3.0 | 0 | 0 |
| Jonathan Babineaux | DT | ATL | 16 | 1 | -2 | -2 | 0 | 1 | 1 | 1 | 31 | 25 | 6 | 3.5 | 6 | 0 |
| John Abraham | DE | ATL | 16 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 35 | 32 | 3 | 10.0 | 7 | 0 |
| Bernard Pollard | SS | BAL | 13 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 98 | 71 | 27 | 2.0 | 7 | 0 |
| Dannell Ellerbe | ILB | BAL | 13 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 92 | 69 | 23 | 4.5 | 2 | 0 |
| Courtney Upshaw | OLB | BAL | 16 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 60 | 38 | 22 | 1.5 | 2 | 0 |
| Arthur Jones | DE | BAL | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 47 | 27 | 20 | 4.5 | 0 | 0 |
| Haloti Ngata | DE | BAL | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 51 | 33 | 18 | 5.0 | 1 | 0 |
| Brendon Ayanbadejo | ILB | BAL | 16 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 43 | 27 | 16 | 1.0 | 1 | 0 |
| Ma'ake Kemoeatu | NT | BAL | 15 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 29 | 15 | 14 | 1.0 | 2 | 0 |
| Ray Lewis | ILB | BAL | 6 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 57 | 44 | 13 | 1.0 | 1 | 0 |
| Albert McClellan | OLB | BAL | 14 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 49 | 36 | 13 | 1.0 | 2 | 0 |
| Paul Kruger | OLB | BAL | 15 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 42 | 30 | 12 | 9.0 | 7 | 0 |
| Cary Williams | CB | BAL | 16 | 4 | 90 | 63 | 1 | 0 | 0 | 0 | 75 | 67 | 8 | 1.0 | 21 | 0 |
| James Ihedigbo | SS | BAL | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 25 | 18 | 7 | 1.0 | 1 | 0 |
| Terrell Suggs | OLB | BAL | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 22 | 17 | 5 | 2.0 | 4 | 0 |
| Pernell McPhee | DE | BAL | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 21 | 18 | 3 | 1.5 | 0 | 0 |
| Omar Brown | DB | BAL | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 1 | 1.0 | 0 | 0 |
| Nick Barnett | OLB | BUF | 16 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 112 | 72 | 40 | 2.0 | 1 | 0 |
| Kelvin Sheppard | MLB | BUF | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 80 | 56 | 24 | 2.0 | 1 | 0 |
| Kyle Williams | DT | BUF | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 46 | 27 | 19 | 5.0 | 2 | 0 |
| Marcell Dareus | DT | BUF | 16 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 39 | 26 | 13 | 5.5 | 6 | 0 |
| Kyle Moore | DE | BUF | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 24 | 14 | 10 | 3.0 | 0 | 0 |
| Mario Williams | DE | BUF | 16 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 46 | 37 | 9 | 10.5 | 4 | 0 |
| Spencer Johnson | DT | BUF | 14 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 19 | 10 | 9 | 2.0 | 2 | 0 |
| Alex Carrington | DE | BUF | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 19 | 12 | 7 | 2.0 | 3 | 0 |
| Shawne Merriman | LB | BUF | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 17 | 12 | 5 | 1.0 | 1 | 0 |
| Chris Kelsay | DE | BUF | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 14 | 12 | 2 | 2.0 | 0 | 1 |
| Mark Anderson | DE | BUF | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 12 | 10 | 2 | 1.0 | 1 | 0 |
| Luke Kuechly | MLB | CAR | 16 | 2 | 22 | 25 | 0 | 0 | 3 | 0 | 164 | 103 | 61 | 1.0 | 10 | 0 |
| Dwan Edwards | DT | CAR | 14 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 52 | 27 | 25 | 6.0 | 1 | 0 |
| Greg Hardy | DE | CAR | 15 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 61 | 41 | 20 | 11.0 | 2 | 0 |
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