| Sacks | ||||||||||||||||
| Interceptions | Fumbles | Tackles | Other | |||||||||||||
| Player | Pos | Team | G | Int | Yds | LG | TD | FF | Rec | TD | Cmb | Solo | Ast | Sack | Pdef | Sfty |
| Charles Johnson | DE | CAR | 16 | 0 | 0 | 0 | 0 | 7 | 1 | 0 | 41 | 30 | 11 | 12.5 | 4 | 0 |
| Von Miller | OLB | DEN | 16 | 1 | 26 | 26 | 1 | 6 | 0 | 0 | 68 | 55 | 13 | 18.5 | 3 | 0 |
| Elvis Dumervil | DE | DEN | 16 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 54 | 32 | 22 | 11.0 | 1 | 1 |
| John Abraham | DE | ATL | 16 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 35 | 32 | 3 | 10.0 | 7 | 0 |
| DeMarcus Ware | OLB | DAL | 16 | 0 | 0 | 0 | 0 | 5 | 1 | 0 | 56 | 33 | 23 | 11.5 | 0 | 0 |
| Rob Ninkovich | DE | NE | 16 | 0 | 0 | 0 | 0 | 5 | 4 | 0 | 58 | 32 | 26 | 8.0 | 1 | 0 |
| J.J. Watt | DE | HOU | 16 | 0 | 0 | 0 | 0 | 4 | 2 | 0 | 81 | 69 | 12 | 20.5 | 16 | 0 |
| Geno Atkins | DT | CIN | 16 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 53 | 39 | 14 | 12.5 | 2 | 0 |
| Quintin Mikell | FS | STL | 16 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 101 | 83 | 18 | 3.0 | 2 | 0 |
| Jerod Mayo | OLB | NE | 16 | 1 | 0 | 0 | 0 | 4 | 1 | 0 | 147 | 88 | 59 | 3.0 | 4 | 0 |
| Aldon Smith | OLB | SF | 16 | 1 | 6 | 6 | 0 | 3 | 0 | 0 | 66 | 50 | 16 | 19.5 | 2 | 0 |
| Cameron Wake | DE | MIA | 16 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 53 | 38 | 15 | 15.0 | 1 | 0 |
| Chris Clemons | DE | SEA | 16 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 40 | 31 | 9 | 11.5 | 4 | 0 |
| Michael Bennett | DE | TB | 16 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 41 | 34 | 7 | 9.0 | 2 | 0 |
| Cameron Jordan | DE | NO | 16 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 66 | 40 | 26 | 8.0 | 3 | 0 |
| Muhammad Wilkerson | DE | NYJ | 16 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 70 | 38 | 32 | 5.0 | 4 | 0 |
| Derrick Johnson | ILB | KC | 16 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 125 | 110 | 15 | 2.0 | 4 | 0 |
| Nick Barnett | OLB | BUF | 16 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 112 | 72 | 40 | 2.0 | 1 | 0 |
| Danieal Manning | FS | HOU | 16 | 2 | 59 | 55 | 1 | 3 | 1 | 0 | 77 | 59 | 18 | 1.0 | 10 | 0 |
| Josh Wilson | CB | WAS | 16 | 2 | 8 | 7 | 0 | 3 | 2 | 1 | 74 | 54 | 20 | 1.0 | 15 | 0 |
| William Gay | CB | ARI | 16 | 2 | 7 | 6 | 0 | 3 | 1 | 0 | 57 | 45 | 12 | 1.0 | 8 | 0 |
| Richard Sherman | CB | SEA | 16 | 8 | 57 | 29 | 1 | 3 | 1 | 0 | 64 | 53 | 11 | 1.0 | 32 | 0 |
| Mario Williams | DE | BUF | 16 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 46 | 37 | 9 | 10.5 | 4 | 0 |
| Shaun Phillips | OLB | SD | 16 | 0 | 0 | 0 | 0 | 2 | 3 | 1 | 50 | 33 | 17 | 9.5 | 3 | 1 |
| Cliff Avril | DE | DET | 16 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 35 | 28 | 7 | 9.5 | 1 | 0 |
| Daryl Washington | ILB | ARI | 16 | 1 | 7 | 7 | 0 | 2 | 1 | 0 | 134 | 108 | 26 | 9.0 | 5 | 0 |
| Ryan Kerrigan | OLB | WAS | 16 | 1 | 28 | 28 | 1 | 2 | 1 | 0 | 54 | 42 | 12 | 8.5 | 9 | 0 |
| Antonio Smith | DE | HOU | 16 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 30 | 22 | 8 | 7.0 | 3 | 0 |
| Corey Wootton | DE | CHI | 16 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 27 | 20 | 7 | 7.0 | 1 | 0 |
| Ahmad Brooks | OLB | SF | 16 | 1 | 50 | 50 | 1 | 2 | 0 | 0 | 46 | 34 | 12 | 6.5 | 7 | 0 |
| Osi Umenyiora | DE | NYG | 16 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 43 | 28 | 15 | 6.0 | 1 | 0 |
| Whitney Mercilus | OLB | HOU | 16 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 25 | 20 | 5 | 6.0 | 1 | 0 |
| Juqua Parker | DE | CLE | 16 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 24 | 18 | 6 | 6.0 | 0 | 0 |
| Lawrence Timmons | ILB | PIT | 16 | 3 | 80 | 53 | 1 | 2 | 1 | 0 | 106 | 75 | 31 | 6.0 | 8 | 0 |
| Brandon Graham | DE | PHI | 16 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 38 | 30 | 8 | 5.5 | 1 | 0 |
| Jo-Lonn Dunbar | OLB | STL | 16 | 2 | 63 | 42 | 0 | 2 | 0 | 0 | 114 | 90 | 24 | 4.5 | 6 | 0 |
| Rob Jackson | OLB | WAS | 16 | 4 | 19 | 17 | 1 | 2 | 1 | 0 | 37 | 26 | 11 | 4.5 | 11 | 0 |
| Larry Foote | ILB | PIT | 16 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 113 | 75 | 38 | 4.0 | 2 | 0 |
| Sam Acho | OLB | ARI | 16 | 2 | 2 | 2 | 0 | 2 | 0 | 0 | 48 | 35 | 13 | 4.0 | 5 | 0 |
| D'Qwell Jackson | MLB | CLE | 16 | 2 | 31 | 27 | 1 | 2 | 2 | 0 | 118 | 63 | 55 | 3.5 | 9 | 0 |
| Philip Wheeler | OLB | OAK | 16 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 109 | 78 | 31 | 3.0 | 6 | 0 |
| Jurrell Casey | DT | TEN | 16 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 54 | 34 | 20 | 3.0 | 0 | 0 |
| Vince Wilfork | DT | NE | 16 | 0 | 0 | 0 | 0 | 2 | 4 | 0 | 48 | 29 | 19 | 3.0 | 6 | 0 |
| Jeremy Mincey | DE | JAC | 16 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 41 | 35 | 6 | 3.0 | 5 | 0 |
| Victor Butler | OLB | DAL | 16 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 25 | 21 | 4 | 3.0 | 3 | 0 |
| Kaluka Maiava | OLB | CLE | 16 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 53 | 35 | 18 | 2.0 | 3 | 0 |
| Terrance Knighton | DT | JAC | 16 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 32 | 20 | 12 | 2.0 | 1 | 0 |
| Morgan Burnett | SS | GB | 16 | 2 | 1 | 1 | 0 | 2 | 1 | 0 | 123 | 88 | 35 | 2.0 | 7 | 0 |
| Paul Posluszny | MLB | JAC | 16 | 3 | 20 | 13 | 0 | 2 | 0 | 0 | 139 | 106 | 33 | 2.0 | 10 | 0 |
| Lance Briggs | OLB | CHI | 16 | 2 | 110 | 74 | 2 | 2 | 0 | 0 | 102 | 73 | 29 | 1.5 | 13 | 0 |
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