| Sacks | ||||||||||||||||
| Interceptions | Fumbles | Tackles | Other | |||||||||||||
| Player | Pos | Team | G | Int | Yds | LG | TD | FF | Rec | TD | Cmb | Solo | Ast | Sack | Pdef | Sfty |
| Ryan Kerrigan | OLB | WAS | 16 | 1 | 28 | 28 | 1 | 2 | 1 | 0 | 54 | 42 | 12 | 8.5 | 9 | 0 |
| Robert Mathis | OLB | IND | 12 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 33 | 22 | 11 | 8.0 | 3 | 0 |
| Everson Griffen | DE | MIN | 16 | 1 | 29 | 29 | 1 | 1 | 2 | 0 | 26 | 23 | 3 | 8.0 | 3 | 0 |
| Jason Pierre-Paul | DE | NYG | 16 | 1 | 28 | 28 | 1 | 1 | 1 | 0 | 66 | 43 | 23 | 6.5 | 6 | 0 |
| Ahmad Brooks | OLB | SF | 16 | 1 | 50 | 50 | 1 | 2 | 0 | 0 | 46 | 34 | 12 | 6.5 | 7 | 0 |
| Akeem Ayers | OLB | TEN | 16 | 1 | 2 | 2 | 0 | 1 | 0 | 0 | 103 | 66 | 37 | 6.0 | 9 | 0 |
| Carlos Dunlap | DE | CIN | 14 | 1 | 14 | 14 | 1 | 4 | 3 | 0 | 40 | 33 | 7 | 6.0 | 4 | 0 |
| Randy Starks | DT | MIA | 16 | 1 | 4 | 4 | 0 | 0 | 0 | 0 | 27 | 18 | 9 | 4.5 | 5 | 0 |
| LaMarr Woodley | OLB | PIT | 13 | 1 | 11 | 11 | 0 | 1 | 1 | 0 | 38 | 27 | 11 | 4.0 | 2 | 0 |
| Jonathan Babineaux | DT | ATL | 16 | 1 | -2 | -2 | 0 | 1 | 1 | 1 | 31 | 25 | 6 | 3.5 | 6 | 0 |
| Chad Greenway | OLB | MIN | 16 | 1 | 3 | 3 | 0 | 0 | 2 | 0 | 148 | 98 | 50 | 3.0 | 5 | 0 |
| Jerod Mayo | OLB | NE | 16 | 1 | 0 | 0 | 0 | 4 | 1 | 0 | 147 | 88 | 59 | 3.0 | 4 | 0 |
| Chase Blackburn | MLB | NYG | 15 | 1 | 0 | 0 | 0 | 4 | 0 | 0 | 98 | 64 | 34 | 3.0 | 7 | 0 |
| Sean Weatherspoon | OLB | ATL | 13 | 1 | 6 | 6 | 0 | 1 | 1 | 0 | 95 | 70 | 25 | 3.0 | 5 | 0 |
| Donald Butler | ILB | SD | 12 | 1 | 21 | 21 | 1 | 2 | 0 | 0 | 77 | 50 | 27 | 3.0 | 5 | 0 |
| Adrian Wilson | SS | ARI | 15 | 1 | -2 | -2 | 0 | 1 | 0 | 0 | 54 | 39 | 15 | 3.0 | 6 | 0 |
| Eugene Sims | DE | STL | 13 | 1 | 5 | 5 | 0 | 0 | 0 | 0 | 20 | 15 | 5 | 3.0 | 2 | 0 |
| Bart Scott | ILB | NYJ | 15 | 1 | 11 | 11 | 0 | 0 | 1 | 0 | 60 | 36 | 24 | 2.5 | 2 | 0 |
| NaVorro Bowman | ILB | SF | 16 | 1 | 11 | 11 | 0 | 1 | 0 | 0 | 149 | 97 | 52 | 2.0 | 7 | 0 |
| Jerrell Freeman | ILB | IND | 16 | 1 | 4 | 4 | 1 | 1 | 0 | 0 | 145 | 90 | 55 | 2.0 | 3 | 0 |
| Lavonte David | OLB | TB | 16 | 1 | 27 | 27 | 0 | 0 | 0 | 0 | 139 | 112 | 27 | 2.0 | 6 | 0 |
| Mason Foster | MLB | TB | 16 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 105 | 82 | 23 | 2.0 | 2 | 0 |
| Paris Lenon | ILB | ARI | 16 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 102 | 73 | 29 | 2.0 | 4 | 0 |
| Bernard Pollard | SS | BAL | 13 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 98 | 71 | 27 | 2.0 | 7 | 0 |
| Stephen Nicholas | OLB | ATL | 16 | 1 | 3 | 3 | 0 | 1 | 1 | 0 | 97 | 72 | 25 | 2.0 | 5 | 0 |
| Miles Burris | OLB | OAK | 16 | 1 | 7 | 7 | 0 | 0 | 0 | 0 | 96 | 62 | 34 | 1.5 | 4 | 0 |
| Dunta Robinson | CB | ATL | 16 | 1 | 4 | 4 | 0 | 1 | 0 | 0 | 80 | 67 | 13 | 1.5 | 9 | 0 |
| Charles Woodson | SS | GB | 7 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 38 | 25 | 13 | 1.5 | 6 | 0 |
| DeMeco Ryans | MLB | PHI | 16 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 113 | 86 | 27 | 1.0 | 5 | 0 |
| Madieu Williams | FS | WAS | 16 | 1 | 24 | 24 | 1 | 0 | 0 | 0 | 99 | 66 | 33 | 1.0 | 7 | 0 |
| K.J. Wright | OLB | SEA | 15 | 1 | 24 | 24 | 0 | 1 | 0 | 0 | 98 | 68 | 30 | 1.0 | 6 | 0 |
| Rahim Moore | FS | DEN | 16 | 1 | 23 | 23 | 0 | 0 | 1 | 0 | 72 | 60 | 12 | 1.0 | 8 | 0 |
| T.J. Ward | SS | CLE | 14 | 1 | 37 | 37 | 0 | 3 | 0 | 0 | 68 | 50 | 18 | 1.0 | 5 | 0 |
| Carlos Rogers | CB | SF | 16 | 1 | 63 | 63 | 0 | 0 | 3 | 1 | 56 | 50 | 6 | 1.0 | 8 | 0 |
| Mike Harris | CB | JAC | 15 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 55 | 51 | 4 | 1.0 | 7 | 0 |
| E.J. Biggers | CB | TB | 13 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 51 | 41 | 10 | 1.0 | 8 | 0 |
| Will Witherspoon | MLB | TEN | 14 | 1 | 40 | 40 | 1 | 1 | 0 | 0 | 47 | 29 | 18 | 1.0 | 3 | 0 |
| Rocky McIntosh | OLB | STL | 16 | 1 | 34 | 34 | 0 | 0 | 0 | 0 | 45 | 34 | 11 | 1.0 | 2 | 0 |
| Tom Zbikowski | SS | IND | 11 | 1 | 20 | 20 | 0 | 0 | 0 | 0 | 38 | 27 | 11 | 1.0 | 6 | 0 |
| Jonathan Vilma | OLB | NO | 11 | 1 | 18 | 18 | 1 | 0 | 0 | 0 | 37 | 20 | 17 | 1.0 | 3 | 0 |
| Troy Polamalu | SS | PIT | 7 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 34 | 29 | 5 | 1.0 | 4 | 0 |
| Jonte Green | CB | DET | 15 | 1 | 18 | 18 | 0 | 0 | 0 | 0 | 29 | 23 | 6 | 1.0 | 5 | 0 |
| Bradley Fletcher | CB | STL | 16 | 1 | 2 | 2 | 0 | 1 | 0 | 0 | 28 | 23 | 5 | 1.0 | 9 | 0 |
| Billy Winn | DT | CLE | 16 | 1 | 0 | 0 | 0 | 0 | 2 | 0 | 26 | 19 | 7 | 1.0 | 4 | 0 |
| L.J. Fort | OLB | CLE | 16 | 1 | 10 | 10 | 0 | 0 | 0 | 0 | 20 | 13 | 7 | 1.0 | 4 | 0 |
| Brice McCain | CB | HOU | 12 | 1 | 86 | 86 | 0 | 0 | 0 | 0 | 24 | 20 | 4 | 0.5 | 9 | 0 |
| Elvis Dumervil | DE | DEN | 16 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 54 | 32 | 22 | 11.0 | 1 | 1 |
| Shaun Phillips | OLB | SD | 16 | 0 | 0 | 0 | 0 | 2 | 3 | 1 | 50 | 33 | 17 | 9.5 | 3 | 1 |
| Kyle Vanden Bosch | DE | DET | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 36 | 28 | 8 | 3.5 | 1 | 1 |
| Connor Barwin | OLB | HOU | 16 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 44 | 35 | 9 | 3.0 | 5 | 1 |
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