| Sacks | ||||||||||||||||
| Interceptions | Fumbles | Tackles | Other | |||||||||||||
| Player | Pos | Team | G | Int | Yds | LG | TD | FF | Rec | TD | Cmb | Solo | Ast | Sack | Pdef | Sfty |
| Kevin Williams | DT | MIN | 16 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 30 | 19 | 11 | 2.0 | 7 | 0 |
| Tom Johnson | DT | NO | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 29 | 19 | 10 | 2.0 | 0 | 0 |
| Kendall Langford | DT | STL | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 27 | 18 | 9 | 2.0 | 2 | 0 |
| Fred Evans | DT | MIN | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 23 | 15 | 8 | 2.0 | 2 | 0 |
| Terrell Suggs | OLB | BAL | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 22 | 17 | 5 | 2.0 | 4 | 0 |
| Ricky Jean Francois | NT | SF | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 22 | 12 | 10 | 2.0 | 0 | 0 |
| Spencer Johnson | DT | BUF | 14 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 19 | 10 | 9 | 2.0 | 2 | 0 |
| Alex Carrington | DE | BUF | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 19 | 12 | 7 | 2.0 | 3 | 0 |
| Nick Perry | OLB | GB | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 18 | 13 | 5 | 2.0 | 1 | 0 |
| Robert Ayers | DE | DEN | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 16 | 8 | 8 | 2.0 | 2 | 0 |
| Jeron Johnson | SS | SEA | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 12 | 7 | 5 | 2.0 | 0 | 0 |
| Mike Daniels | DE | GB | 14 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 12 | 12 | 0 | 2.0 | 1 | 0 |
| Corey Williams | DT | DET | 7 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 9 | 5 | 4 | 2.0 | 0 | 0 |
| Steve McLendon | DT | PIT | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 7 | 4 | 3 | 2.0 | 0 | 0 |
| Jarius Wynn | DE | TEN | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 6 | 0 | 2.0 | 1 | 0 |
| Greg Scruggs | DE | SEA | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 5 | 1 | 2.0 | 1 | 0 |
| NaVorro Bowman | ILB | SF | 16 | 1 | 11 | 11 | 0 | 1 | 0 | 0 | 149 | 97 | 52 | 2.0 | 7 | 0 |
| Lavonte David | OLB | TB | 16 | 1 | 27 | 27 | 0 | 0 | 0 | 0 | 139 | 112 | 27 | 2.0 | 6 | 0 |
| Mason Foster | MLB | TB | 16 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 105 | 82 | 23 | 2.0 | 2 | 0 |
| Paris Lenon | ILB | ARI | 16 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 102 | 73 | 29 | 2.0 | 4 | 0 |
| Bernard Pollard | SS | BAL | 13 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 98 | 71 | 27 | 2.0 | 7 | 0 |
| Stephen Nicholas | OLB | ATL | 16 | 1 | 3 | 3 | 0 | 1 | 1 | 0 | 97 | 72 | 25 | 2.0 | 5 | 0 |
| Morgan Burnett | SS | GB | 16 | 2 | 1 | 1 | 0 | 2 | 1 | 0 | 123 | 88 | 35 | 2.0 | 7 | 0 |
| Bobby Wagner | MLB | SEA | 16 | 3 | 55 | 45 | 0 | 0 | 0 | 0 | 140 | 86 | 54 | 2.0 | 7 | 0 |
| Paul Posluszny | MLB | JAC | 16 | 3 | 20 | 13 | 0 | 2 | 0 | 0 | 139 | 106 | 33 | 2.0 | 10 | 0 |
| Nick Roach | OLB | CHI | 16 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 66 | 51 | 15 | 1.5 | 4 | 0 |
| Courtney Upshaw | OLB | BAL | 16 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 60 | 38 | 22 | 1.5 | 2 | 0 |
| Leroy Hill | OLB | SEA | 13 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 47 | 31 | 16 | 1.5 | 0 | 0 |
| Sen'Derrick Marks | DT | TEN | 14 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 41 | 30 | 11 | 1.5 | 3 | 0 |
| Jarret Johnson | OLB | SD | 15 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 40 | 27 | 13 | 1.5 | 0 | 0 |
| Darnell Dockett | DE | ARI | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 34 | 23 | 11 | 1.5 | 4 | 0 |
| Paul Soliai | DT | MIA | 16 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 29 | 18 | 11 | 1.5 | 2 | 0 |
| Kyle Love | DT | NE | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 25 | 11 | 14 | 1.5 | 0 | 0 |
| Josh Brent | NT | DAL | 12 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 22 | 13 | 9 | 1.5 | 1 | 0 |
| Pernell McPhee | DE | BAL | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 21 | 18 | 3 | 1.5 | 0 | 0 |
| Cameron Heyward | DE | PIT | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 20 | 13 | 7 | 1.5 | 0 | 0 |
| Larry English | LB | SD | 14 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 13 | 7 | 6 | 1.5 | 0 | 0 |
| Jason Babin | DE | JAC | 5 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 11 | 7 | 4 | 1.5 | 0 | 0 |
| Miles Burris | OLB | OAK | 16 | 1 | 7 | 7 | 0 | 0 | 0 | 0 | 96 | 62 | 34 | 1.5 | 4 | 0 |
| Dunta Robinson | CB | ATL | 16 | 1 | 4 | 4 | 0 | 1 | 0 | 0 | 80 | 67 | 13 | 1.5 | 9 | 0 |
| Charles Woodson | SS | GB | 7 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 38 | 25 | 13 | 1.5 | 6 | 0 |
| Usama Young | FS | CLE | 13 | 3 | 44 | 44 | 0 | 0 | 1 | 0 | 53 | 37 | 16 | 1.5 | 10 | 0 |
| Karlos Dansby | MLB | MIA | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 133 | 100 | 33 | 1.0 | 9 | 0 |
| Vontaze Burfict | OLB | CIN | 16 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 127 | 73 | 54 | 1.0 | 2 | 0 |
| Curtis Lofton | MLB | NO | 16 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 123 | 82 | 41 | 1.0 | 7 | 0 |
| Rey Maualuga | MLB | CIN | 16 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 122 | 62 | 60 | 1.0 | 4 | 0 |
| Brandon Spikes | MLB | NE | 15 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 92 | 57 | 35 | 1.0 | 7 | 0 |
| Yeremiah Bell | SS | NYJ | 16 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 89 | 72 | 17 | 1.0 | 2 | 0 |
| Mychal Kendricks | OLB | PHI | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 75 | 58 | 17 | 1.0 | 9 | 0 |
| Rolando McClain | MLB | OAK | 11 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 60 | 37 | 23 | 1.0 | 0 | 0 |
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