The Rams were without cornerback Fakhir Brown (ankle) and offensive guards Richie Incognito (illness) and Jacob Bell (hamstring). Adam Goldberg and John Greco moved up as the starting guards. Jonathan Wade was the fill-in for Brown at right cornerback.
The Rams made other lineup changes that were not attributed to injuries: Victor Adeyanju started for Leonard Little at left defensive end; Adam Carriker replaced La'Roi Glover at defensive tackle; and Chris Draft moved ahead of Will Witherspoon as the starting middle linebacker. Little, Glover and Witherspoon were in uniform.