Manning needed 19 yards to reach the milestone. He did it on a 5-yard completion to Pierre Garcon in the first quarter of Sunday's game against the Houston Texans.
That could be the first of many accomplishments for Manning on Sunday. If the Colts win, Manning will tie Fran Tarkenton for fourth place on the career wins list for quarterbacks with 125. He also needs four touchdown passes to become the first in league history to throw for 300 in a decade.
Among his accomplishments this season, Manning became the fastest quarterback to 4,000 completions and passed Tarkenton for third place on the career touchdowns list.