Clark hit the milestone by making all five catches for 53 yards during the Colts' second possession against the Buffalo Bills on Sunday. Clark's fifth catch came on a dump pass over the middle from Peyton Manning that went for 10 yards and provided Indianapolis a first down at the Bills 1.
Mike Hart scored on a 1-yard run two plays later to tie the game at 7.
Gonzalez had 102 catches with Kansas City in 2004.
Manning hit 4,500 yards passing for only the second time in his career, playing only three series before taking to the bench in the season finale on a cold, snow-filled day.
In making his 192nd straight start, Manning went 14 of 18 for 95 yards and an interception before taking a seat on a heated bench on the sideline against the Bills. He was replaced by rookie Curtis Painter with 9:13 left in the second quarter and the game tied at 7.
His final pass was a screen to Clark that lost 7 yards. If he doesn't return, Manning will finish with 4,500 yards passing, 57 short of matching his career high in 2004.
The Colts (14-1), the AFC's top-seeded team, have a first-round bye in the playoffs.