Vick was leveled by New England Patriots linebacker Jermaine Cunningham after heaving a deep pass. Vick knelt on one knee, while surrounded by medical personnel, got up and walked to the sideline under his own power with 6:01 left in the quarter.
He was replaced by third-round draft pick Nick Foles. Trent Edwards also was expected to play quarterback against the Patriots.
Vick, entering his fourth season with the Eagles, was hurt on his sixth play. He left after completing one of three passes for 5 yards and running once for 5 yards.