Nicks has missed the past two games and coach Tom Coughlin said Thursday that Nicks won't be available against the Browns. That complicates New York's passing game because backup Ramses Barden has a concussion and his status is uncertain.
Safety Antrel Rolle said he won't be sidelined with a left knee problem, and the Giants certainly could use him in a secondary plagued by injuries. The other starting safety, Kenny Phillips (right knee), is out, and cornerback Corey Webster is playing with a broken right hand.
"Whenever I am not out there, it is not anything I will ever be comfortable with," said Rolle, who also didn't practice Thursday. Neither did Webster nor linebacker Michael Boley (hip), who also said he expects to play against Cleveland.
"You've just got to be smart about a lot of things in this league and we are doing it."
Also missing practice Thursday was defensive tackle Rocky Bernard (quadriceps).