The Raiders said he was questionable to return.
Oakland's leading rushing went to the locker room late in the second quarter Sunday. It was unclear how he was injured.
The Raiders drafted McFadden fourth overall out of Arkansas in 2008. He has proven to be one of the NFL's most dangerous running backs the past two seasons when healthy.
But the problem for McFadden and the Raiders has been his health in recent years. McFadden has missed 19 games in his first four seasons with foot, toe, shoulder, knee and hamstring injuries.