Sproles, a running back and return specialist, was injured in last week's loss at Denver. The team says he will be reevaluated this week.
Linebacker David Hawthorne, who has started three games for the Saints, was inactive. New Orleans decided to sit Hawthorne after giving up more than 400 yards in their first seven games.
Receiver Mardy Gilyard, safety Nate Allen, defensive end Vinny Curry, quarterback Trent Edwards, offensive tackle Nate Menkin, defensive end Darryl Tapp and offensive guard Danny Watkins were inactive for the Eagles.