Brown sprained his right ankle in last Sunday's 24-20 victory over the New York Giants. Coach Mike Tomlin called Brown's status "very much in doubt." Brown leads the Steelers with 42 receptions and is second on the team with 499 receiving yards.
The Steelers will also be without safety Troy Polamalu, who will miss his fifth straight game and seventh overall with a right calf injury. Running back Jonathan Dwyer, who sat out last week with a right quad injury, is expected to play.