Coach Mike Mularkey ruled Jones-Drew out Friday, but said he's hopeful Jones-Drew will be able to play in next week's season finale at Tennessee.
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Backup running back Rashad Jennings also was ruled out for Sunday's game against New England (10-4). Jennings passed his concussion test but has a shoulder injury and missed practice all week. Montell Owens will make his third consecutive start.
The Jaguars (2-12) haven't activated linebacker Daryl Smith (groin) from injured reserve, but Mularkey said he will play "a pretty significant role" against New England. Smith hasn't played all season.