| Transactions |
| Date | Player | POS | Transaction |
|---|
| June 22, 2017 | Tyrunn Walker | DE | cut |
| June 21, 2017 | Brian Randolph | DB | cut |
| June 21, 2017 | Ejuan Price | DE | signed/draft choice, Four-year contract (through 2020) |
| June 21, 2017 | Josh Reynolds | WR | signed/draft choice, Four-year contract (through 2020) |
| June 21, 2017 | Sam Rogers | FB | signed/draft choice, Four-year contract (through 2020) |
| June 21, 2017 | Tanzel Smart | DT | signed/draft choice, Four-year contract (through 2020) |
| June 20, 2017 | Marquez North | WR | cut |
| June 20, 2017 | Reggie Northrup | LB | cut |
| June 20, 2017 | Teidrick Smith | LB | cut |
| June 15, 2017 | Dylan Thompson | QB | cut |
| June 12, 2017 | Cooper Kupp | WR | signed/draft choice, Four-year contract (through 2020) |
| June 12, 2017 | Gerald Everett | TE | signed/draft choice, Four-year contract (through 2020) |
| June 12, 2017 | John Johnson | SAF | signed/draft choice, Four-year contract (through 2020) |
| May 30, 2017 | Dylan Thompson | QB | signed |
| May 16, 2017 | Austin Blythe | C | acquired from waiver |
| May 16, 2017 | Teidrick Smith | LB | signed |
| May 15, 2017 | Austin Blythe | C | cut |
| May 11, 2017 | Aaron Murray | QB | cut |
| May 11, 2017 | Travis Wilson | TE | signed |
| May 8, 2017 | Omarius Bryant | DT | cut |
| May 5, 2017 | Omarius Bryant | DT | signed |
| May 5, 2017 | Alex Kozan | G | signed |
| May 5, 2017 | Dominique Easley | DT | re-signed/rest FA, One-year tender (through 2017) |
| May 5, 2017 | Kwayde Miller | T | signed |
| May 3, 2017 | Andrew East | LS | cut |
| May 3, 2017 | Brandon Wegher | RB | cut |
| May 3, 2017 | Jerome Couplin | DB | cut |
| May 3, 2017 | Mike Purcell | NT | acquired from waiver |
| May 2, 2017 | Mike Purcell | NT | cut |
| May 1, 2017 | David Arkin | G | cut |
| May 1, 2017 | Dravious Wright | CB | signed |
| May 1, 2017 | Jake Eldrenkamp | C | signed |
| May 1, 2017 | Justin Davis | RB | signed |
| May 1, 2017 | Troy Hill | CB | suspended, 2 games (NFL Substance Abuse Policy) |
| Apr 19, 2017 | Kevin Short | DB | cut |
| Apr 12, 2017 | Aaron Donald | DT | team exercises option, Fifth-year option on rookie contract |
| Apr 11, 2017 | Stedman Bailey | WR | cut |
| Apr 10, 2017 | Ethan Westbrooks | DE | re-signed/rest FA, One-year contract (through 2017) |
| Apr 10, 2017 | Louis Trinca-Pasat | DT | re-signed/excl. FA, One-year tender (through 2017) |
| Apr 10, 2017 | Matt Longacre | DE | re-signed/excl. FA, One-year tender (through 2017) |
| Apr 10, 2017 | Mike Purcell | NT | re-signed/excl. FA, One-year tender (through 2017) |
| Apr 7, 2017 | Nickell Robey-Coleman | DB | signed, One-year contract (through 2017) |
| Apr 5, 2017 | Carlos Thompson | LB | signed, One-year contract (through 2017) |
| Apr 5, 2017 | John Sullivan | C | signed/unrest FA, One-year contract (through 2017) |
| Mar 23, 2017 | Tyrunn Walker | DE | signed/unrest FA, One-year contract (through 2017) |
| Mar 16, 2017 | Connor Barwin | LB | signed, One-year contract (through 2017) |
| Mar 16, 2017 | Lance Dunbar | RB | signed/unrest FA, One-year contract (through 2017) |
| Mar 14, 2017 | Andrew East | LS | signed, One-year contract (through 2017) |
| Mar 14, 2017 | Greg Zuerlein | K | re-signed/unrest FA, Three-year contract (through 2019) |
| Mar 14, 2017 | Kayvon Webster | DB | signed/unrest FA, Two-year contract (through 2018) |
| Mar 9, 2017 | Robert Woods | WR | Declared Free Agent |
| Mar 9, 2017 | Andrew Whitworth | T | Declared Free Agent |
| Mar 9, 2017 | Lance Dunbar | RB | Declared Free Agent |
| Mar 9, 2017 | Kayvon Webster | DB | Declared Free Agent |
| Mar 9, 2017 | Tyrunn Walker | DE | Declared Free Agent |
| Mar 9, 2017 | Aaron Murray | QB | signed |
| Mar 9, 2017 | Andrew Whitworth | T | signed/unrest FA, Three-year contract (through 2019) |
| Mar 9, 2017 | Chase Reynolds | RB | Declared Free Agent |
| Mar 9, 2017 | Dominique Easley | DT | Restricted Free Agent |
| Mar 9, 2017 | Ethan Westbrooks | DE | Restricted Free Agent |
| Mar 9, 2017 | Eugene Sims | DE | cut |
| Mar 9, 2017 | Greg Zuerlein | K | Declared Free Agent |
| Mar 9, 2017 | Robert Woods | WR | signed/unrest FA, Five-year contract (through 2021) |
| Mar 9, 2017 | Tre Mason | RB | cut |
| Mar 9, 2017 | Trey Watts | RB | cut |
| Mar 9, 2017 | Connor Barwin | LB | cut |
| Mar 9, 2017 | John Sullivan | C | Declared Free Agent |
| Mar 6, 2017 | Nickell Robey-Coleman | DB | cut |
| Mar 6, 2017 | Trumaine Johnson | CB | re-signed/franchise, One-year tender (through 2017) |
| Feb 28, 2017 | Trumaine Johnson | CB | Designated franchise player, non-exclusive franchise tag |
