Panthers QB Cam Newton vs. Broncos OLB Von Miller: This matches the top overall pick from last year's draft (Newton) vs. the second pick (Miller). Newton has tailed off some this season, but Miller continues to play at a high level. Miller will have to get pressure off the edge to help contain Newton, who did play well last week at Washington.
Bears DE Julius Peppers vs. Texans LT Duane Brown: Peppers moves up and down the line, but he will spend time against Brown, who is one of the best in the league. Peppers can win with speed or power, which makes him a tough opponent. But Brown is a fighter and has really improved in pass protection.
Vikings C John Sullivan vs. Lions DT Ndamukong Suh: Sullivan is having a heck of a year in the middle for the Vikings and is a big reason why Adrian Peterson has run so well. Suh is not having a good year and is underachieving. He needs to get it going.
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Giants RG Chris Snee vs. Bengals DT Geno Atkins: Snee has battled some ankle injuries this week, but he is expected to play. Atkins is a tough player to handle when you are healthy, let alone dinged. He will be key to getting pressure inside against Eli Manning. If Snee can't go, the Giants will likely move tackle David Diehl inside to guard.
Buccaneers WR Vincent Jackson vs. Chargers CB Quentin Jammer: Jackson gets a chance to make his former team pay for letting him leave. He is averaging over 20 yards per catch, so he will be the big-play guy. Jammer has trouble at times in man coverage, so look for the Bucs to attack him.
Ravens OLB Terrell Suggs vs. Raiders OT Jared Veldheer: Suggs is back and that's huge for the Ravens' defense. He can set the edge, and he can rush the passer. Veldheer is a solid left tackle who has had some good games against some good pass rushers.
Cowboys WR Dez Bryant vs. Eagles CB Nnamdi Asomugha: Asomugha has really struggled this season and now must face Bryant in man coverage. The problem is Bryant tends to disappear at times. The Cowboys need to get him more involved in this game.
Eagles LT King Dunlap and RT Demetress Bell vs. Cowboys OLB DeMarcus Ware: Dunlap and Bell had big problems last week against the Saints, a team without much of a pass rush. Ware has to be licking his chops. I would imagine he might spend a lot of time with Michael Vick. Would five sacks be a surprise?
Bills DE Mario Williams vs. Patriots RT Sebastian Vollmer: Vollmer has played well this season. Williams has not. But Williams has the ability to turn it on with his talent. He has to get pressure on Tom Brady if Buffalo is to have a chance.
Chiefs WR Dwayne Bowe vs. Steelers CB Ike Taylor: Bowe is the big-play threat in Kansas City, but he is playing with limited talent at quarterback. Even so, I expect them to try and get Bowe going here. Taylor is up and down. He is beatable.