Saints QB Drew Brees vs. the Seattle secondary: The Seattle secondary is one of the best in football, but it will be without Brandon Browner and Walter Thurmond. That means Jeremy Lane and Byron Maxwell will play. Look for Brees to attack those two and stay away from Richard Sherman.
Seahawks LT Russell Okung vs. Saints DE Cameron Jordan: Jordan has emerged as a force this season for the Saints defense. Okung is a Pro Bowl-caliber tackle, but he's battled injuries this season. Jordan is relentless, so there is no let up ever when playing him.
Texans WR Andre Johnson vs. Patriots CB Aqib Talib: Johnson remains a top-level receiver and Talib has shutdown skills when he is matched up with the best. The problem for Johnson last week was Case Keenum. He was off. These two will get after it.
Eagles RB LeSean McCoy vs. Cardinals' second-ranked run defense: McCoy leads the NFL in rushing and the Cardinals are tough to run on. That will make this a fun battle to watch. Can the Eagles spread out the Cardinals and run it like they have against so many defenses?
Eagles WR DeSean Jackson vs. Cardinals CB Patrick Peterson: Peterson is a top-level corner when it comes to matching up with the opposition's best receiver. He has the ability to take them away. But Jackson will provide a stiff test with his quickness and speed. Peterson is physical, so I would expect him to use that against the smaller Jackson.
Chargers' offensive line vs. Bengals' defensive line: The Chargers had to play last week without left tackle King Dunlap, which forced rookie D.J. Fluker from the right side to the left side. And he left the game late with a knee injury, that isn't believed to be serious. Whoever starts will have to deal with Carlos Dunlap and Michael Johnson off the edges. That's tough duty.
Can Redskins QB Robert Griffin III get it going?: There are many who want to see him benched. That's absurd. He is their long-term answer, so he has to play through his troubles. What would it help to sit him down? He just needs to play better and get better protection.
Can the Chiefs get a pass rush with a hurting Tamba Hali and without Justin Houston? The last time the Chiefs faced the Broncos, they didn't get near Peyton Manning. And that was with Hali and Houston. Houston is out this week, and Hali will be playing on a bad ankle. The Chiefs might be forced to blitz more.
Broncos OLB Von Miller vs. Chiefs tackles: Miller wasn't a real factor in the first meeting, but he looked good last week against the Patriots. He will move from the right side to the left side, so look for him to cause problems coming off both edges.