Pierre-Marc Bouchard and Pavol Demitra each added two assists for the Wild (2-0).
Petteri Nummelin, a 33-year-old who played in the Swiss League the last five years, also scored for Minnesota. Marian Gaborik and Demitra added the Wild's other goals.
Keith Tkachuk and Lee Stempniak tallied goals for the Blues (0-2).
St. Louis led 2-1 when Curtis Sanford replaced Manny Legace in goal at 10:38 of the second period. Sanford allowed three goals on five shots in the period, allowing Minnesota to grab a 4-2 lead before the second intermission.
Minnesota outshot St. Louis 25-22 in the game and 20-10 in the final two periods.
Tkachuk's goal came on a 5-on-3 power-play at 9:26 of the first, one of three 5-on-3 advantages for the Blues in the opening period.
Josh Harding stopped 20 shots to get the win.