Patrick O'Sullivan scored on the power play for the Hurricanes, who fell to 1-2 overall and 0-2 at home this preseason.
Anders Lindback made 15 saves for Nashville (1-1) after coming on midway through the second to relieve Mark Dekanich, who finished with six stops. Justin Pogge stopped 25 shots for the Hurricanes.
Tootoo scored the go-ahead goal with 7:54 left in the second, beating Pogge with a blast in transition.
That goal came minutes after Legwand tied it. Pogge left the puck behind the net a teammate, but Legwand skated in, snatched it up and scored on a wraparound.
O'Sullivan put the Hurricanes up 1-0 late in the first with time winding down during a two-man advantage.
He took a feed from Anton Babchuk behind the right circle and unloaded a slap shot that got past Dekanich. O'Sullivan, who grew up in Winston-Salem and signed with Carolina last week, had two goals in two nights against Nashville and three points in three preseason games.