Can Big Ben and the Steelers keep pace with the division-leading Bengals? They'll have to get past the Seahawks -- in Seattle. Will Brock Osweiler give the Broncos a fighting chance against the 10-0 Patriots?
Defensive standouts like Von Miller and Josh Norman can likely count on being tagged, but what about players like Kirk Cousins, Michael Crabtree and Alshon Jeffery?
All eyes are on the three unbeatens, especially the Patriots as Bill Belichick, Tom Brady and the 8-0 Pats head to New York to face the one team that's had their number in recent years. Could the Titans trip up the Panthers? Or the Texans ambush the Bengals?
Fortunes can be made or lost in a contract year, and players like Josh Norman, Eric Berry, Michael Crabtree and Doug Martin are on pace to cash in big. On the other end, Sam Bradford and Alfred Morris are losing value.
Broncos cornerback Aqib Talib was hit with a costly penalty late in the game against the Colts.
Peyton Manning needs three more passing yards to have the most of any quarterback in NFL history.
In a week lacking marquee matchups, the Packers traveling to Carolina to battle the unbeaten Panthers for NFC surpremacy is as good as it gets.
The Cowboys are talked about on Twitter. A lot.
A look back at some of the great defenses since 1980 in the NFL shows several common threads with all of them, and a closer look at Denver's current unit shows they're following that same path to success.
The Vikings are establishing themselves as one of the better teams in the NFL and no one's talking about them.

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