Is Joe Philbin's job on the line in London? If Drew Brees plays, will he be able to zip it with that shoulder? Can the lions save their season in Seattle?
Cal quarterback Jared Goff isn't a no-brainer No. 1 pick like Andrew Luck, but he has separated himself as the top passing prospect if he enters the 2016 class and the Bears desperately need to address the position.
If the Steelers are going to hold on against the Rams, they'll have to do it without Pro Bowl quarterback Ben Roethlisberger.
The Rams are built to inflict pain on quarterbacks and Aaron Donald is going to wreak havoc. If Miami keeps it simple, I believe they can win this game by a touchdown or more.
Will the Packers have better results vs. Seattle's D? Watt vs. Oher. Who steps up in Dallas? Can Dalton do it again?
Yeah, it's only Week 2, but trust us, plenty of these showdowns could be pivotal for setting the tone for the season. And there isn't a game that sets the tone more than Rex Ryan squaring off with his old nemesis, Bill Belichick.
Tom Brady is on top of CBSSports.com's first MVP projection list of 2015.
The Chiefs are big risers after an impressive Week 1 performance in the 2015-16 Super Bowl odds.
Who's got next in the NFL? Blake Bortles, Jeremy Hill and Khalil Mack are among 24 youngsters yet to make a Pro Bowl who are ready for their star turn.
The Seahawks are the top favorite to win the Super Bowl in 2016 heading into the 2015 regular season.

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