Tyrod Taylor is back, Sammy Watkins is (hopefully) healthy and LeSean McCoy is still going strong. The Bills have some good Fantasy options, and Zay Jones and Jonathan Williams are also potential sleepers.
After your choice at No. 1 overall, which is likely Le'Veon Bell, David Johnson or Ezekiel Elliott, your toughest decision could be what to do at the Round 2-3 turn. Jamey Eisenberg shows you what he did with his team at No. 1 overall.
Is it smart to draft three running backs with your first four picks? Yes, if you get the right three running backs as Jamey Eisenberg did here after getting Antonio Brown at No. 4 overall with Todd Gurley, Lamar Miller and Joe Mixon.